ArticleUnited European gastroenterology journal2025
Differential Outcomes of Early Versus Late Anti-TNF Therapy in Ulcerative Colitis and Crohn's Disease: A Nationwide Propensity Score-Matched Cohort Study.
Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Early Bird May Not Always Catch the Worm: Reframing Anti-TNF Timing.United European gastroenterology journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundEarly advanced inflammatory bowel disease (IBD) therapy is emphasised to prevent disease progression and restore quality of life.
aimsTo evaluate the potential advantages of early versus late anti-tumour necrosis factor (TNF) therapy in patients with IBD.
methodsThis retrospective study included patients with newly diagnosed IBD (2004-2018) who received anti-TNF therapy and had at least 1 year of follow-up. Patients were categorised as early or late users based on a 2-year post-diagnosis cut-off for first anti-TNF exposure. Outcomes included IBD-related surgeries, hospitalizations, emergency department (ED) visits, and drug persistence. Subgroup analysis examined concurrent immunomodulator use, and sensitivity analyses were employed 6 months or 1 year post-diagnosis cut-offs.
resultsAmong 8105 patients with ulcerative colitis (UC) and 8465 with Crohn's disease (CD), distinct outcomes emerged. Early anti-TNF users with UC had significantly higher hospitalization (hazard ratio [HR] 1.34, 95% confidence interval [CI] 0.91-1.96) and ED visit rates (HR 1.30, 95% CI 1.16-1.46) compared with late users. In CD, early users showed a non-significant trend toward fewer event rates. Drug persistence was longer among late users for both UC and CD. In UC, combining immunomodulators with early anti-TNF increased hospitalization and ED visits but not in CD. Sensitivity analyses confirmed the primary findings.
conclusionsWhile early anti-TNF use was associated with differential outcomes in CD, the relationship between treatment timing and clinical course diverged in UC, challenging the assumption that early intervention is universally advantageous across IBD subtypes. These findings underscore the need for further research to identify patient subgroups that might benefit most from early intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.