Evidence map›Paper›PMID 40553503›Full record

ArticleeLife2025

Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation.

Nobuyuki Nosaka, Vanessa Borges, Daisy Martinon, Timothy R Crother, Moshe Arditi, Kenichi Shimada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nobuyuki Nosaka *Department of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, United States.ORCID https://orcid.org/0000-0002-7722-0701
Vanessa Borges *Department of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, United States.
Daisy MartinonDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, United States.
Timothy R CrotherDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, United States.ORCID https://orcid.org/0000-0001-8465-6127
Moshe ArditiDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, United States.
Kenichi ShimadaDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, United States.ORCID https://orcid.org/0000-0001-8213-5686

Funding

Sequential release of IL-1alpha and IL-1beta leads to a two-hit model of acute lung injuryR01HL130353 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHIMADA, KENICHI · 2016 to 2020
$2.2M
NHLBI NIH HHS HL130353-01NHLBI NIH HHS R01 HL130353
6 · The paper itself

Abstract

Although mechanical ventilation is a critical intervention for acute respiratory distress syndrome (ARDS), it can trigger an IL-1β-associated complication known as ventilator-induced lung injury. In mice, we found that lipopolysaccharide (LPS) and high-volume ventilation, LPS-HVV, lead to hypoxemia with neutrophil extracellular traps (NETs) formation in the alveoli. Furthermore,

Indexed as

Extracellular TrapsHypothermia, InducedInterleukin-1betaVentilator-Induced Lung InjuryAnimalsLipopolysaccharidesMacrophagesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinIL1B protein, mouseInterleukin-1betaLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinacuteARDSimmunologyinflammationlungmacrophagesmouseneutrophilsventilator

Identifiers

PMID40553503
PMCPMC12187133

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.