ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Evan W DavisDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-5430-3934
Margaret A ParkDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0009-0007-2606-6496
Toni L BasinskiDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0009-0002-9537-578X
J Pablo ArnolettiSurgical Oncology, Orlando Health Cancer Institute, Orlando, Florida.ORCID 0009-0007-8757-4398
Mark BloomstonSurgical Oncology, Lee Health Cancer Institute, Fort Myers, Florida.ORCID 0009-0002-9398-7301
Tiffany L CarsonDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-8180-4523
Tiago Biachi De CastriaDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-6832-2485
Dung-Tsa ChenDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-5026-415X
Sylvia L CrowderDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-1430-9810
Maria Genilo-DelgadoDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-2094-977X
Wade G DouglasDepartment of Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida.ORCID 0000-0002-6863-3504
Kevin L HuguetDepartment of Surgery, St. Anthony's Hospital, St. Petersburg, Florida.ORCID 0009-0002-2007-8617
Kun JiangDepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-8531-7813
Pamela J HodulDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-2004-2702
Aleksandra KarolakDepartment of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-8430-7138
Dae Won KimDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-0332-6175
John M KoomenDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-3818-1762
Anjana A MenonDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0009-0005-0590-4150
Qianxing MoDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-0021-7694
Shaffer R MokDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-8734-5260
Manuel A Molina-VegaHollis Cancer Center, Lakeland Regional Health, Lakeland, Florida.ORCID 0009-0001-9342-0535
Lina Moreno-UrazanDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0009-0000-2848-8659
Sabeen AhmedDepartment of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-0456-3073
Nathan H ParkerDepartment of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-8947-7942
Jose M PimientoDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-7237-4509
Ghulam RasoolDepartment of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-8551-0090
Lauren M SparksTranslational Research Institute, AdventHealth, Orlando, Florida.ORCID 0000-0002-8724-6016
Paul A StewartDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.ORCID 0000-0003-0882-308X
Alexandra F TassielliDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0009-0009-1445-8227
Jamie K TeerDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-4513-0282
Jose G TrevinoDepartment of Surgery, University of Florida, Gainesville, Florida.ORCID 0000-0002-0265-8151
Vic VelanovichUniversity of South Florida/Tampa General Hospital, Tampa, Florida.ORCID 0000-0003-0133-948X
Xuefeng WangDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-5775-408X
Christopher J WhelanDepartment of Metabolism and Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-7511-2603
Sarah M JudgeDepartment of Physical Therapy, University of Florida, Gainesville, Florida.ORCID 0000-0002-3974-0247
Andrew R JudgeDepartment of Physical Therapy, University of Florida, Gainesville, Florida.ORCID 0000-0002-4488-291X
Jason B FlemingHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-8796-5627
Mokenge P MalafaDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-2716-4315
Daniel JeongDepartment of Diagnostic Imaging, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-4510-5204
Jennifer B PermuthDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-4726-9264
Florida Pancreas Collaborative
Funding
Florida Department of Health (DOH) 8JK02National Cancer Institute (NCI) P30-CA076292National Cancer Institute (NCI) P30-CA240139U.S. Department of Defense (DOD) W81XWH-22-1-1021 LOG#PA210192
6 · The paper itself
Abstract
backgroundMuscle loss influences pancreatic ductal adenocarcinoma (PDAC) outcomes, but treatment-related edema may cause overestimation of total skeletal muscle area (tSMA), confounding our understanding of muscle changes. However, no studies have quantified the impact of edema on tSMA and psoas skeletal muscle area (pSMA) changes. Thus, we sought to (i) assess the impact of edema on tSMA and pSMA changes between diagnosis and follow-up and (ii) explore the utility of pSMA as a clinically relevant measure of muscle and muscle loss among patients with PDAC.
methodsBody composition was measured using CT scans at diagnosis and follow-up from 95 patients enrolled in the Florida Pancreas Collaborative cohort study. Edema was assessed by opacifications in subcutaneous fat, and tSMA and pSMA changes were expressed as percent change between diagnosis and follow-up. We used multivariable generalized linear models to estimate mean tSMA and pSMA changes overall and by edema status. Spearman correlation was used to measure interrelationships of tSMA and pSMA.
resultstSMA increased between diagnosis and follow-up (Δ = 0.66) but only in patients with edema (Δ = 3.35) whereas non-edematous patients lost tSMA (Δ = -2.03). Conversely, pSMA decreased regardless of edema status. Furthermore, tSMA and pSMA were strongly correlated overall (r = 0.75) and in non-edematous patients (r = 0.83).
conclusionsEdema inflated estimates of tSMA at follow-up in patients with PDAC, but pSMA was impervious to edema and may represent a suitable proxy for tSMA. IMPACT: pSMA is a reliable measure of muscle and muscle loss and should be considered in future studies assessing muscle loss in patients with PDAC.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma. · full record | OpenQuestion