Evidence map›Paper›PMID 40553369›Full record

ArticleCEN case reports2025

NELL-1-positive membranous nephropathy following gastric cancer in an older living kidney donor: a case report.

Mamiko Hashimoto, Erika Hishida, Yuko Ono, Takuya Murakami, Mami Hirata, Maki Kinoshita, Toshimi Imai, Tetsu Akimoto, Daisuke Nagata

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mamiko HashimotoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Erika HishidaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. e-hishida@dokkyomed.ac.jp.ORCID 0000-0003-4141-1933
Yuko OnoDepartment of Pathology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan.
Takuya MurakamiDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Mami HirataDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Maki KinoshitaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Toshimi ImaiDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Tetsu AkimotoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Daisuke NagataDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Living kidney transplantation is an established treatment for end-stage kidney disease (ESKD). While rare, the donors may develop de novo glomerular diseases post-donation. We report a case of membranous nephropathy (MN) in an 80-year-old male, diagnosed 9 years post-donation. The patient had a history of early gastric cancer treated with endoscopic submucosal dissection one year post-donation. Routine follow-up revealed asymptomatic proteinuria (4.27 g/gCr). The kidney biopsy demonstrated MN with IgG1/IgG3-dominant deposits and NELL-1 positivity. Recent evidence suggests NELL-1-positive MN may occur independently of malignancy in older individuals. Notably, MN developed 8 years after cancer remission with no evidence of recurrence. The patient achieved complete remission with conservative therapy consisting of an angiotensin receptor blocker and dietary modification. This case underscores the need for vigilant long-term follow-up in older kidney donors and illustrates how early proteinuria detection facilitates timely management of de novo glomerulopathies.

Indexed as

Glomerulonephritis, MembranousKidney TransplantationLiving DonorsStomach NeoplasmsAged, 80 and overBiopsyHumansKidneyMaleProteinuriaDe novo glomerulopathyNELL-1-positive membranous nephropathyOlder kidney donorsRemote malignancy history

Identifiers

PMID40553369
PMCPMC12457253

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.