ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Burden of syphilis among people living with HIV: a large cross-sectional study from Türkiye.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Ocular Syphilis in the Era of Resurgence: Clinical Characteristics and Diagnostic Challenges in a Single-Center Cohort.Medicina (Kaunas, Lithuania) · 2026Article
- Unusual Presentation of Syphilis a Case Report: Areolar Condyloma Lata in a Patient with Human Immunodeficiency Virus Infection.International journal of women's health · 2026Article
- Article
- The Resurgence of Syphilis: A 20-Year Evaluation of Epidemiological Trends and Serological Test Performance Using Rapid Plasma Reagin and Indirect Hemagglutination Assays.Medicina (Kaunas, Lithuania) · 2025Article
- Atypical Dermatological Manifestations of Syphilis in Advanced HIV: A Case-Based Narrative Review.Mediterranean journal of hematology and infectious diseases · 2025Article
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Abstract
backgroundSyphilis and HIV are closely linked infections with shared transmission routes and risk factors. Despite effective screening and treatment options, the prevalence of syphilis remains high among people living with HIV (PLWH), especially in middle-income countries like Türkiye.
objectivesTo investigate the seroprevalence of syphilis among PLWH using centralized laboratory data and to assess its distribution by age and sex.
methodsA retrospective cross-sectional study was conducted by reviewing data derived from blood specimens submitted to our laboratory for routine CD4⁺ T cell enumeration, ultimately analyzing 2,768 PLWH between January 2022 and December 2024. Syphilis seropositivity was defined by concurrent positivity in both VDRL and TPHA tests. Demographic and clinical variables were analyzed using SPSS v.22.0.
resultsSyphilis seropositivity was detected in 923 patients (33.3%). The prevalence was significantly higher among males (37.0%) compared to females (6.1%) (p < 0.001). The highest seroprevalence was observed in patients aged 31-40 years (37.4%). There was no significant difference in mean age between syphilis-positive and syphilis-negative groups (p > 0.05).
conclusionThis study reveals a high burden of syphilis among PLWH in Türkiye, particularly in younger male populations. The findings underscore the necessity for routine syphilis screening, targeted prevention strategies, and integrated STI care within HIV programs.
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