Evidence map›Paper›PMID 40553321›Full record

ReviewJapanese journal of radiology2025

Contrast medium dose optimization in the era of multi-energy CT.

Yasunori Nagayama, Takeshi Nakaura, Kazuo Awai, Kazuhiro Katahira, Satoru Takahashi, Noriko Oyama-Manabe, Satoshi Goshima, Yasuyuki Kobayashi, Takamichi Murakami, Toshinori Hirai and 1 more

Abstract readReview
In one paragraph

Review in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yasunori NagayamaDepartment of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. y.nagayama1980@gmail.com.ORCID http://orcid.org/0000-0003-3280-7346
Takeshi NakauraDepartment of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Kazuo AwaiDepartment of Diagnostic Radiology, Kumamoto Chuo Hospital, 1-5-1 Taishima, Minami-ku, Kumamoto, 862-0965, Japan.
Kazuhiro KatahiraDepartment of Diagnostic Radiology, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan.
Satoru TakahashiImaging Research Center, Takatsuki General Hospital, 1-3-13 Kosobe-cho, Takatsuki, Osaka, 569-1192, Japan.
Noriko Oyama-ManabeDepartment of Radiology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan.
Satoshi GoshimaDepartment of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
Yasuyuki KobayashiDepartment of Medical Information and Communication Technology Research, Graduate School of Medicine, St. Marianna Univereity School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan.
Takamichi MurakamiDepartment of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Toshinori HiraiDepartment of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Masahiro JinzakiDepartment of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the increasing use of contrast-enhanced CT, optimizing the iodinated contrast medium (ICM) dose while maintaining diagnostically adequate image quality is essential to mitigate potential adverse effects on patients, the environment, and public health, as well as to reduce medical costs and address potential supply shortages. Multi-energy CT technologies including dual-energy CT and photon-counting detector CT enable data acquisition at multiple energy spectra, allowing for material characterization beyond the capabilities of conventional single-energy CT. Recent technical advancements and the growing adoption of these technologies in clinical practice have enhanced patient care across various diagnostic tasks. Among the spectral-based imaging options offered by multi-energy CT, virtual monoenergetic imaging holds significant promise for substantial ICM dose reduction due to the drastic improvement in iodine contrast at lower energy levels. This article aims to provide an overview of multi-energy CT technology and its utility for ICM dose optimization across various clinical indications, while also discussing current issues and related topics.

Indexed as

Contrast MediaRadiation DosageTomography, X-Ray ComputedHumansRadiography, Dual-Energy Scanned ProjectionContrast MediaDual-energy CTIodinated contrast mediumIodine k-edgeLow X-ray energyMulti-energy CTPhoton-counting detector CT

Identifiers

PMID40553321
PMCPMC12575512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.