Evidence map›Paper›PMID 40553313›Full record

ReviewMolecular biology reports2025

Dermatophytosis in context of Trichophyton rubrum: host defense mechanisms, virulence factors, and treatment innovations.

Khushboo Arya, Saumya Chaturvedi, Sana Akhtar Usmani, Shikha Chandra, Nitin Bhardwaj, Manoj Kumar, Sonam Kumari, Rajendra Prasad, Ashutosh Singh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Optimizing MALDI-TOF MS for routine dermatophyte identification, including Trichophyton indotineae.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khushboo AryaDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India.
Saumya ChaturvediDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India.
Sana Akhtar UsmaniDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India.
Shikha ChandraDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India.
Nitin BhardwajDepartment of Zoology and Environmental Science, Gurukula Kangri Vishwavidyalaya, Haridwar, 249404, Uttarakhand, India.
Manoj KumarCSIR-Indian Institute of Toxicology Research, Lucknow, Lucknow, 226 001, Uttar Pradesh, India.
Sonam KumariIndian Council of Medical Research, New Delhi, India.
Rajendra PrasadAmity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon, Gurugram, Haryana, India.
Ashutosh SinghDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India. singh_ashutosh@lkouniv.ac.in.

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR38505/MED/29/1513/2020Department of Science and Technology, Ministry of Science and Technology, India CRG/2022/001047Higher Education, Government of Uttar Pradesh No. 10/2021/281/-4-Sattar-2021-04(2)/2021Indian Council of Medical Research No 3/1/3/JRF2021/HRD(LS)Indian Council of Medical Research No.52/08/2019-BIO/BMSUniversity Grants Commission NTA Ref. No. 22161023985
6 · The paper itself

Abstract

Dermatophytosis is a superficial fungal infection caused by a group of keratinophilic fungi, which can sometimes be invasive. Factors like its contagious nature, widespread impact, resistance to treatment, and the fact that it is recurrent and highly impacts the quality of life make it more serious. This review will delve into the intricacies of infection caused by Trichophyton rubrum. T. rubrum is the most common and potent infectious agent among all the dermatophytes. Reported worldwide, it causes chronic infections in humans. These infections are difficult to manage due to frequently encountered cross-resistance to known antifungals. Independent studies have implicated the roles of several proteins in virulence and pathogenesis mechanisms. In this review, we have discussed research advances in the field of host-pathogen interaction, virulence factors, drug development, drug resistance mechanism and other technological progress concerning T. rubrum mediated dermatophytosis.

Indexed as

ArthrodermataceaeTineaTrichophytonVirulence FactorsAntifungal AgentsDrug Resistance, FungalHost-Pathogen InteractionsHumansVirulenceAntifungal AgentsVirulence FactorsDrug resistanceEpidemiologyPathogenesisTrichophyton rubrumVirulence

Identifiers

PMID40553313

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.