ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025
Phenolic Extracts with Antioxidant and Anticancer Potential from Araticum Fruits (Annona crassiflora Mart.), a Native Brazilian Plant.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The native Brazilian fruit, araticum, contains a high amount of phenolics, leading to a strong antioxidant capacity, which makes it a potential source of anticancer agents. This study aimed to use different pre-treatments to improve the efficiency of phenolic extraction and evaluate its bioactive activity. Different pre-treatments, including ultrasound and microwave, were used to increase the extraction yield. Microwave-assisted pre-treatment enhanced both the phenolic yield and antioxidant activity of extracts significantly. Specifically, gallic acid content increased from 131.35 to 156.94 mg/100 g fresh fruit, while the oxygen radical absorbance capacity doubled, rising from 60.1 to 123.2 µmol TE/g fresh fruit. In addition, the colon cancer cell proliferation assay showed that araticum phenolic extracts, especially with microwave-assisted pre-treatment, have strong antiproliferative capability with low IC50 value, ranging from 8.06 µg/mL to 33.52 µg/mL. The possible anticancer targets and inhibition mechanisms have been predicted by PharmMapper and StringDB. The phenolic extract of araticum exhibits strong bioactivities, suggesting its potential as a health-promoting ingredient for chemoprevention.
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