Evidence map›Paper›PMID 40553216›Full record

ArticleBrain imaging and behavior2025

Brain structural reorganization mediates the relationship between hearing loss and cognitive impairment.

Yao Wang, Jianfen Luo, Wenqing Li, Yu Han, Wen Ma, Siqi Liu, Lei Xu, Zhaomin Fan, Yu Ai, Meixia Su and 4 more

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yao Wang *Department of Biomedical Engineering, School of Life Sciences, Tiangong University, Tianjin, China.
Jianfen Luo *Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Wenqing LiDepartment of Biomedical Engineering, School of Life Sciences, Tiangong University, Tianjin, China.
Yu HanDepartment of Biomedical Engineering, School of Life Sciences, Tiangong University, Tianjin, China.
Wen MaDepartment of Otolaryngology, the Central Hospital of Jinan City, Cheeloo College of Medicine, Shandong University, Jinan, China.
Siqi LiuDepartment of Biomedical Engineering, School of Life Sciences, Tiangong University, Tianjin, China.
Lei XuDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Zhaomin FanDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Yu AiDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Meixia SuDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Fuxin RenDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Fuyan LiDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. fuyanli1234@sina.com.
Haibo WangDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China. whboto11@163.com.
Fei GaoDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. feigao@email.sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Presbycusis is a common disease in the elderly linked to cognitive decline. Studies have shown structural alterations in brain regions associated with hearing and cognitive function in presbycusis patients. However, the neural mechanisms linking brain structure with hearing loss and cognitive impairment remain unclear. This study investigated neuroanatomical alterations associated with auditory and cognitive functions. A total of 67 presbycusis patients and 68 normal-hearing controls underwent magnetic resonance imaging, auditory assessment, and cognitive assessment. Presbycusis patients were divided into presbycusis cognitive preservation (presbycusis-CP) and presbycusis cognitive impairment (presbycusis-CI) subgroups according to Montreal Cognitive Assessment scores. Atrophy of gray matter volume (GMV) was observed in presbycusis patients. The results indicated that GMV of the hippocampus, superior frontal cortex (SFC), and posterior cingulate cortex (PCC) mediated the connection between hearing loss and cognitive impairment. Interestingly, the hippocampus mediated the relationship between the GMV of the SFC and PCC in presbycusis and with the strongest mediating effect (56.14%) in presbycusis-CI patients. Notably, this was not valid in normal-hearing controls and presbycusis-CP patients. Overall, patients with presbycusis, especially presbycusis-CI patients, exhibit a distinct reorganization pattern in auditory and cognitive-related brain areas, with the hippocampus potentially being a key target for presbycusis-related cognitive impairment.

Indexed as

BrainCognitive DysfunctionHearing LossAgedAtrophyFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedPresbycusisBrain area reorganizationCognitive impairmentHippocampusMRIPresbycusis

Identifiers

PMID40553216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.