Evidence map›Paper›PMID 40553180›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Alport syndrome complicated with steroid-sensitive nephrotic syndrome: a case report.

Qian Fu, Yuling Luo, Xingfeng Yao, Hui Wang

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qian FuDepartment of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Yuling LuoSchool of Pediatrics, Capital Medical University, Beijing, China.
Xingfeng YaoDepartment of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Hui WangDepartment of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. wanghui@bch.com.cn.ORCID 0000-0002-1123-9186

Funding

Hebei Natural Science Foundation H2022104021National Key R&D Plan (14th Five Year Plan) 2022YFC2705100
6 · The paper itself

Abstract

At 2 years and 4 months old, a girl presented with microscopic hematuria, mild edema, and nephrotic-range proteinuria with hypoalbuminemia and hypercholesterolemia without other extrarenal manifestations. She had a family history of microscopic hematuria. Kidney biopsy revealed a glomerular basal membrane of uneven thickness combined with podocytopathy. Genetic testing revealed a heterozygous c.3499G > A (p.Gly1167Arg) variant in COL4A3, which has been reported as a pathogenic variant of autosomal dominant Alport syndrome; this variant was inherited from her father. Treatment with steroids and immunosuppressants was effective. Podocytopathy should be considered in Alport syndrome patients with a young age of onset and nephrotic-range proteinuria. Electron microscopy plays an important role in diagnosis.

Indexed as

Nephritis, HereditaryNephrotic SyndromeAutoantigensChild, PreschoolCollagen Type IVFemaleHumansImmunosuppressive AgentsTreatment OutcomeAutoantigensCollagen Type IVImmunosuppressive Agentstype IV collagen alpha3 chainAlport syndromeIV collagen geneNephrotic syndromePodocytopathyProteinuria

Identifiers

PMID40553180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.