ArticleCurrent microbiology2025
Characterization of Penicillin-Non-Susceptible, Multidrug-Resistant Streptococcus agalactiae Using Whole-Genome Sequencing.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Clinical and Epidemiological Landscape of Antimicrobial Resistance and Virulence inAntibiotics (Basel, Switzerland) · 2026Review
- Penicillin-Binding Proteins inAntibiotics (Basel, Switzerland) · 2026Review
- Increase in Penicillin Non-Susceptibility in Group B Streptococci Alongside Rising Isolation Rates-Based on 24 Years of Clinical Data from a Single University Hospital.Antibiotics (Basel, Switzerland) · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Streptococcus agalactiae (group B Streptococcus, GBS) is a major pathogen in neonates and adults causing neonatal sepsis, pneumonia, and meningitis. Although penicillin is the first-line treatment, GBS infections have developed multidrug resistance, including non-susceptibility to penicillin. Given a lack of molecular genetic research, further characterization of clinical isolates is essential. Therefore, in this study, we aimed to advance our understanding of their resistance profiles and molecular epidemiology of penicillin-non-susceptible GBS isolates. We conducted a comprehensive analysis of the genetic characteristics of penicillin-non-susceptible, multidrug-resistant (MDR) GBS and antimicrobial susceptibility testing. Four penicillin-non-susceptible GBS isolates were obtained from clinical specimens. Antimicrobial susceptibility was assessed using VITEK2, MicroScan, broth microdilution, and Etest. Whole-genome sequencing was conducted using the Illumina MiSeq platform, followed by sequence analysis of resistance-related genes, including pbp, ciaH, rpo, and quinolone resistance determinants. The clinical data of patients were also reviewed. All four isolates exhibited penicillin minimum inhibitory concentrations (MICs) of 0.25 μg/mL and were resistant to levofloxacin, erythromycin, clindamycin, and tetracycline, as determined by antimicrobial susceptibility testing, confirming an MDR phenotype. The MICs of cefotaxime and ceftriaxone were close to the susceptibility breakpoints, indicating borderline susceptibility. Several amino acid substitutions in penicillin-binding proteins were associated with penicillin non-susceptibility and additional substitutions in CiaH and RpoD. Substitutions associated with fluoroquinolone resistance were also identified in GyrA and ParC. All isolates carried the resistance genes erm(B), mre(A), and tet(M). Although rare, the detection of these isolates underscores the need for continued surveillance and further research to inform effective treatment and prevention strategies.
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Registered trials
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