Evidence map›Paper›PMID 40553152›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Right ventricular function in pulmonary hypertension and obesity: a cross-sectional cohort study with survival follow-up.

B Egenlauf, M Braun, V Schiffer, A M Marra, P Xanthouli, S Harutyunova, C A Eichstaedt, C Erbel, R Schell, F Linden and 2 more

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

B EgenlaufCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
M BraunCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
V SchifferCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
A M MarraDepartment of Translational Medical Sciences, "Federico II" University and School of Medicine, Naples, Italy.
P XanthouliCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
S HarutyunovaCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
C A EichstaedtCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
C ErbelDepartment of Cardiology, Pneumology and Angiology at University Hospital, Heidelberg University Hospital, Heidelberg, Germany.
R SchellDepartment of Cardiology, Pneumology and Angiology at University Hospital, Heidelberg University Hospital, Heidelberg, Germany.
F LindenDepartment of Cardiology, Pneumology and Angiology at University Hospital, Heidelberg University Hospital, Heidelberg, Germany.
E GrünigCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.
Nicola BenjaminCentre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany. nicola.benjamin@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity or underweight can complicate and aggravate symptoms and progression of right heart failure in patients with pulmonary arterial hypertension (PAH). This study investigates the influence of different body mass index (BMI) categories on right heart function and outcome in PAH patients.

methodsIn this cross-sectional study with survival follow-up (mean follow-up 3.1 ± 2.6 years, median 2.7 years), clinical measures such as WHO-functional class and invasively measured hemodynamic parameters at initial diagnosis of PAH were compared between different BMI groups.

resultsOut of 2055 data sets, 755 patients with PAH (62.5% female) were eligible for the study (65 ± 15 years, 44.9% idiopathic PAH, 64.8% WHO functional class III or IV). Out of them 15 patients (1.99%) were underweight (BMI < 18 kg/m

conclusionsThis is the first study to assess RV function with regard to BMI status and survival in PAH. The study underlines the importance of the parameter body weight in the clinical management of PAH patients. It provides important insights in the relations of BMI and CO and documented significant gender differences.

Indexed as

Hypertension, PulmonaryObesityVentricular Dysfunction, RightVentricular Function, RightAgedBody Mass IndexCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisSurvival RateCardiac outputEchocardiographyObesity paradoxPulmonary hypertensionRight-heart catheterizationRight ventricular functionSurvival

Identifiers

PMID40553152
PMCPMC12894162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.