Evidence map›Paper›PMID 40553121›Full record

ArticleVirchows Archiv : an international journal of pathology2026

Pleomorphic adenoma arising in salivary heterotopia-cyst complex of parathyroid: a rare origin for ectopic salivary gland neoplasia.

Haley Corbin, Linwah Yip, Diana Bell, Raja R Seethala

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Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haley CorbinDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. corbinhn@upmc.edu.ORCID http://orcid.org/0000-0002-0079-4459
Linwah YipDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Diana BellDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Raja R SeethalaDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of an early pleomorphic adenoma arising in salivary heterotopia (SH) with an associated Kürsteiner cyst, all in the fat adjacent to a hypercellular parathyroid. The association of SH-cyst complexes with parathyroid is a recurring finding with suggested origin from Kürsteiner canals (KC), which are putative embryologic remnants of the developing thymus and inferior parathyroid glands in the third branchial pouches. We subsequently established the immunophenotype for KC (SOX-10 positive, parathyroid hormone negative, PAX-9 variable) and confirmed that the cysts of SH-cyst complexes do indeed have this phenotype and as expected, share SOX-10 positivity with the acinar and intercalated duct components of SH. Our case shows an intimate association with ductal elements, plasmacytoid myoepithelial cells, and HMGA2 reactivity, justifying designation as an incipient pleomorphic adenoma. Thus, this incidental finding provides another rare but plausible rationale for primary salivary gland tumors in the neck without a known primary.

Indexed as

Adenoma, PleomorphicChoristomaCystsParathyroid GlandsSalivary Gland NeoplasmsSalivary GlandsAdultBiomarkers, TumorFemaleHumansImmunohistochemistryMaleMiddle AgedBiomarkers, TumorCystKürsteiner canalsParathyroidPleomorphic adenomaSalivary heterotopia

Identifiers

PMID40553121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.