ArticleResearch in psychotherapy (Milano)2025
The role of oxytocin as an indicator of outcome and therapeutic alliance.
Article in Research in psychotherapy (Milano), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Trait-Like and State-Like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder.Psychotherapy and psychosomatics · 2025Article
- How factors of the therapeutic alliance interact with oxytocin neurotransmission in psychotherapy.Frontiers in psychiatry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin is a neuropeptide produced by the hypothalamus and involved in numerous functions, such as labor and breastfeeding. The literature has highlighted the critical role of this hormone in interpersonal relationships - particularly in mother-child and sentimental relationships - implicating it in attachment bonds. Several recent studies have examined the activation of oxytocin in the psychotherapeutic relationship. This narrative review article describes the modulation of the oxytocinergic axis in patients and therapists, based on a review of papers identified through searches of PsycINFO, PubMed, and RivistaWeb, from January 2015 to May 2024. The results of this literature review support the hypothesis that changes in oxytocin levels during interactions between therapist and patient are associated with the therapeutic process by activating the attachment system. Furthermore, this mechanism does not appear to be influenced by the therapist's theoretical model of reference but rather by their ability to empathize with the patient. In conclusion, this mini-review highlights the significant function of oxytocin as a potential biomarker for assessing the patient-therapist relationship, identifying a biological substrate of the therapeutic alliance.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.