Evidence map›Paper›PMID 40552930›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2025

Toward a Next-Generation Liquid Biopsy for HPV+ HNSCC: Opportunities, Challenges, and the Road Ahead.

Catherine T Haring, Melina J Windon, Molly E Heft-Neal, J Chad Brenner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catherine T Haring *Department of Otolaryngology - Head and Neck Surgery, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-9317-6536
Melina J Windon *Department of Otolaryngology - Head and Neck Surgery, University of Kentucky, Lexington, Kentucky.ORCID 0000-0002-0904-2931
Molly E Heft-Neal *Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-8813-5537
J Chad BrennerDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-3238-1111

Funding

Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Defining the Role of HPV Integration Structures in HNSCC Molecular HeterogeneityR01DE032699 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner, RYAN E MILLS · 2024 to 2026
$1.8M
American Cancer Society (ACS)National Institute of Dental and Craniofacial Research (NIDR) R01-DE032699National Institute of General Medical Sciences (NIGMS) T32-GM145470NIDCR NIH HHS R01 DE032699NIGMS NIH HHS T32 GM145470
6 · The paper itself

Abstract

Human papillomavirus (HPV) whole-genome sequencing-based plasma ctDNA analysis has demonstrated high diagnostic accuracy in identifying HPV-positive head and neck cancer, supporting the potential for future clinical validation through biomarker advancement paradigms. In this issue, we discuss how this research opens exciting future directions for liquid biopsy research and clinical implementation for HPV+ head and neck squamous cell carcinoma. See related article by Bryan et al., p. 3483.

Indexed as

Biomarkers, TumorHead and Neck NeoplasmsPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckCirculating Tumor DNAHigh-Throughput Nucleotide SequencingHumansLiquid BiopsyPapillomaviridaeWhole Genome SequencingBiomarkers, TumorCirculating Tumor DNA

Identifiers

PMID40552930
PMCPMC12353175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.