ArticleACS applied materials & interfaces2025
Multifunctional Hydrogel with Synergistic Reactive Oxygen Species Scavenging and Macrophage Polarization-Induced Osteo-immunomodulation for Enhanced Bone Regeneration.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- [Microenvironmental dysregulation and advances in functional biomaterial-based interventions for diabetic bone defect repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Interface Modulation and Lithium Dendrite Suppression of LLTO via Synergistic KH560-PDA Co-Grafting for PVDF-HFP Composite Solid Electrolytes.Materials (Basel, Switzerland) · 2026Article
- Potentiating mild photothermal therapy via CDK12/13-mediated AKT suppression to orchestrate ferroptosis-apoptosis crosstalk for vaccine-like immunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Black Phosphorus Nanomaterials and the Senescent Osteoimmune Microenvironment: Mechanisms, Opportunities, Challenges, and Future Outlook.International journal of nanomedicine · 2026Review
- A Needlelike Nano-hydroxyapatite-Based Hydrogel Accelerates Critical Bone Defect Regeneration via Osteo-/Angiogenesis and Osteoimmune Regulation.Biomaterials research · 2026Article
- Nanozymes for Bone Regeneration: Mechanistic Insights into Immune and Metabolic Microenvironment Modulation.International journal of nanomedicine · 2026Review
- The role of gut microbiota in osteoporosis: underlying mechanisms, clinical associations, and emerging biomaterials.Frontiers in immunology · 2026Review
- Functionalized GelMA-based hydrogels for osteoimmunomodulation and bone regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
- Recent advances in piezoelectric hydrogels for osteoarthritis therapy: material design, signal transduction, and clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Mild photothermal-mediated neuroimmunomodulatory composite hydrogel ameliorates bone healing microenvironment for enhanced osteoporotic bone defect regeneration.Materials today. Bio · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regeneration of bone defects remains an enormous clinical challenge owing to locally abnormal reactive oxygen species (ROS) levels and the inability to timely regulate the osteoimmune microenvironment. Herein, polydopamine (PDA) modified black phosphorus nanosheets (BP) with small palladium nanoparticles (Pd NPs) immobilized in situ were prepared (BP@PDA-Pd) and incorporated into a gelatin methacryloyl/methacrylated poly-γ-glutamate hybrid hydrogel to fabricate a composite photocurable therapeutic platform (BPPP/GP) with excellent antioxidant and osteo-immunomodulatory activity for enhanced high-quality endogenous bone regeneration. The BPPP with optical absorbance in the near-infrared (NIR) region endows the composite hydrogel with excellent NIR-responsive characteristics, resulting in mild photothermal-enhanced antioxidant enzyme-like activity to scavenge ROS and the induction of endogenous cell recruitment. More importantly, the BPPP/GP photocurable hydrogel with mild photothermal stimulation could achieve spatiotemporal regulation of the osteoimmune microenvironment by inducing macrophage polarization toward the anti-inflammatory phenotype (M2), with the secretion of pro-osteogenic and pro-angiogenic growth factors. In vivo experiments confirmed that the NIR-stimulation based BPPP/GP system could effectively eliminate ROS, alleviate local inflammation, and regulate macrophage polarization to create a favorable osteoimmune microenvironment for osteogenic differentiation and revascularization. Together, the development of this multifunctional hydrogel with the capability to reshape the damaged microenvironment provides a promising strategy for accelerating bone regeneration.
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