Evidence map›Paper›PMID 40552829›Full record

ArticlemBio2025

Evidence that hPIV2 paramyxovirus antigenomes are edited during infection.

Keisuke Ohta, Junna Kawasaki, Daniel Kolakofsky, Machiko Nishio, Yusuke Matsumoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keisuke OhtaDepartment of Microbiology, School of Medicine, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0003-4317-7407
Junna KawasakiGraduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-6609-5300
Daniel KolakofskyDepartment of Microbiology and Molecular Medicine, University of Geneva School of Medicine, Geneva, Switzerland.
Machiko NishioDepartment of Microbiology, School of Medicine, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0002-5311-5798
Yusuke MatsumotoTransboundary Animal Diseases Research Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.ORCID 0000-0003-3500-2279

Funding

Japan Agency for Medical Research and Development 23fk0108687h0001Kato Memorial Bioscience Foundation noneKieikai Research Foundation noneTakeda Science Foundation none
6 · The paper itself

Abstract

Mononegavirus genomes contain IMPORTANCE: We have assumed that paramyxovirus editing signals would operate strictly during mRNA synthesis, as it apparently makes no sense to edit antigenomes. Nevertheless, there is evidence here that the opposite is the case. If so, this alters our view of paramyxovirus replication, and we summarize what is known about how its RNA-dependent RNA polymerase carries out its task of expressing alternate open reading frames during mRNA synthesis.

Indexed as

Parainfluenza Virus 2, HumanRNA EditingGenome, ViralHumansRNA, MessengerRNA, ViralVirus ReplicationRNA, MessengerRNA, ViralparamyxovirusRNA editingrule of sixviral replication

Identifiers

PMID40552829
PMCPMC12345181

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.