Evidence map›Paper›PMID 40552815›Full record

ArticleJournal of bacteriology2025

A novel membrane stress response that blocks chromosomal replication by targeting the DnaA initiator via the ClpP protease.

Alabi Gbolahan, Tong Li, Rishit Saxena, Karen Wolcott, Aamna Sohail, Ishika Ahmed, Dhruba K Chattoraj, Elliott Crooke, Rahul Saxena

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alabi Gbolahan *Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Tong LiDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Rishit SaxenaDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Karen WolcottBasic Research Laboratory, Center for Cancer Research, National Institutes of Health, National Cancer Institute, Bethesda, Maryland, USA.
Aamna SohailDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Ishika AhmedDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Dhruba K ChattorajBasic Research Laboratory, Center for Cancer Research, National Institutes of Health, National Cancer Institute, Bethesda, Maryland, USA.
Elliott CrookeDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Rahul Saxena *Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.ORCID 0000-0003-4252-1368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In IMPORTANCE: The observation that DNA replication stress can block cell division in

Indexed as

Bacterial ProteinsCell MembraneChromosomes, BacterialDNA-Binding ProteinsDNA ReplicationEndopeptidase ClpEscherichia coliEscherichia coli ProteinsStress, PhysiologicalGene Expression Regulation, BacterialProtease LaBacterial ProteinsClpP protease, E coliDnaA protein, BacteriaDNA-Binding ProteinsEndopeptidase ClpEscherichia coli ProteinsProtease LaClpP proteaseDNA replicationLon proteasemembrane stress(p)ppGppstress response

Identifiers

PMID40552815
PMCPMC12288453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.