Evidence map›Paper›PMID 40552800›Full record

ArticleMicrobiology spectrum2025

HCV Ab titer and ALT level indicate occult hepatitis C virus infection in treatment-naive HCV Ab-positive and HCV Ab-negative patients: a 3-year prospective cohort study.

Ming-Ling Chang, Wei-Ting Chen, Li-Heng Pao, Cheng-Hsun Chiu, Rong-Nan Chien

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ming-Ling ChangDivision of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.ORCID 0000-0003-4902-4401
Wei-Ting ChenDivision of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Li-Heng PaoGraduate Institute of Health Industry Technology, Research Center for Food and Cosmetic Safety, and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Cheng-Hsun ChiuDepartment of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0003-4324-7743
Rong-Nan ChienDivision of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Funding

Chang Gung Memorial Hospital CMRPG1N0111~3, CMRPG3L1191~2, CMRPG3M0211~3, CMRPG1K0111~3 and CORPG3P0591~3National Science Council, Taiwan MOST 113-2629-B-182A-002-
6 · The paper itself

Abstract

The phenotype of occult hepatitis C virus (HCV) infection (OCI) in anti-HCV treatment-naive patients remains elusive. A prospective 3-year cohort study of 218 anti-HCV treatment-naive patients was conducted. OCI was defined as positive HCV RNA in peripheral blood mononuclear cells (PBMCs) of patients with negative serum HCV RNA. Among the 128 HCV antibody (Ab)-positive patients, 15 (11.7%) had OCI; higher HCV Ab titers were noted in patients with OCI than in those without OCI (84.25 ± 64.76 vs 46.60 ± 46.07 ng/mL,

Indexed as

Alanine TransaminaseHepacivirusHepatitis CHepatitis C AntibodiesAdultAgedCardiovascular DiseasesFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRNA, ViralAlanine TransaminaseHepatitis C AntibodiesRNA, Viralcardiovascularcryptogenic hepatitisHCV AbOCItreatment-naive

Identifiers

PMID40552800
PMCPMC12323646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.