Evidence map›Paper›PMID 40552714›Full record

ArticleeLife2025

Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in

Alexandros Papagiannakis, Qiwei Yu, Sander K Govers, Wei-Hsiang Lin, Ned S Wingreen, Christine Jacobs-Wagner

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes.Protein science : a publication of the Protein Society · 2026
    Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Alexandros PapagiannakisHoward Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0002-6363-804X
Qiwei YuLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.ORCID https://orcid.org/0000-0003-0610-3484
Sander K GoversHoward Hughes Medical Institute, Stanford University, Stanford, United States.
Wei-Hsiang LinHoward Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0001-8177-5892
Ned S WingreenLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.ORCID https://orcid.org/0000-0001-7384-2821
Christine Jacobs-WagnerHoward Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0003-0980-5334

Funding

Thermally robust chemotaxis and thermotaxis in Escherichia coliR01GM082938 · NIGMS · PRINCETON UNIVERSITY · PI WINGREEN, NED S · 2008 to 2025
$5.5M
Dutch Research Council Rubicon Science 2018-1 019.181EN.018NIGMS NIH HHS R01 GM082938NIH HHS R01 GM082938
6 · The paper itself

Abstract

Chromosome segregation is essential for cellular proliferation. Unlike eukaryotes, bacteria lack cytoskeleton-based machinery to segregate their chromosomal DNA (nucleoid). The bacterial ParABS system segregates the duplicated chromosomal regions near the origin of replication. However, this function does not explain how bacterial cells partition the rest (bulk) of the chromosomal material. Furthermore, some bacteria, including

Indexed as

Chromosomes, BacterialChromosome SegregationEscherichia coliPolyribosomesGene Expression Regulation, Bacterialcell biologycytoplasmic heterogeneityE. colinon-equilibrium processesnucleoid segregationphase separationpolysome dynamicssingle-cell microscopy

Identifiers

PMID40552714
PMCPMC12187137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.