ArticleJournal of cosmetic dermatology2025
The Reduction of Skin Photodamage by the Ectoine-Thermus thermophilus Cofermentation Products.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Reduction of Skin Photodamage by the Ectoine-Thermus thermophilus Cofermentation Products.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundProlonged exposure to UVB (280-320 nm) can lead to skin oxidative damage, inflammatory response, and skin cancer. Many active ingredients in the fermentation products of Thermus thermophilus have been shown to play important roles in antioxidant and anti-UVB photodamage, such as superoxide dismutase (SOD) and photolyase. Ectoine, as one of the most prevalent compatible solutes in halophilic bacteria, can protect cells, proteins, cell membranes, and nucleic acids from external extreme environments such as high temperature, freezing, irradiation, and drying. It has been applied in the industries of fine chemicals, biomedicine, and biomanufacturing worldwide.
aimsIn this study, we evaluated the antioxidant activities and anti-UVB photodamage activities of Ectoine-T. thermophilus cofermentation products (D-Ectoine).
methodsThe comparison between D-Ectoine and Ectoine was analyzed with hydroxyl radical (OH·
resultsThe results showed that D-Ectione could promote the GSH-PX activity in HSF cells with stronger T-AOC and DPPH scavenging capacity, reduce the expression of LPS-induced inflammatory factors IL-6 and IL-8, increase Col I expression both with and without UVB and inhibit expression of MMP-1 after UVB irradiation. In the 3D skin model, D-Ectione could increase the number of cell survival and Nrf2 expression, and decrease 8-OHdG expression after UVB irradiation.
conclusionsThese results demonstrated that D-Ectione has protective effects against UVB-induced skin photodamage and may contribute to the development of cosmetic products with anti-UVB.
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Registered trials
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