Evidence map›Paper›PMID 40552591›Full record

ArticleThe Journal of laryngology and otology2025

Bilateral radiation-induced squamous cell carcinoma of the external auditory canal: the effect of immunosuppressive therapy.

Cole Needham, Jonn Wu, Desmond A Nunez

Abstract read
In one paragraph

Article in The Journal of laryngology and otology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cole NeedhamDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0009-0004-6554-1999
Jonn WuBritish Columbia Cancer Agency-Vancouver Centre, Vancouver, BC, Canada.
Desmond A NunezDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0002-7501-9625

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSquamous cell carcinoma of the external auditory canal is rare, with bilateral cases even rarer. We report the management of a patient with bilateral external auditory canal squamous cell carcinoma related to radiotherapy and immunosuppression. CASE REPORT: A 47-year-old woman with a history of radiotherapy 14 years prior and renal transplantation 6 years prior presented with bilateral external auditory canal squamous cell carcinoma. Squamous cell carcinoma was excised with a purely surgical approach. The two operations included a tympanic membrane graft to preserve hearing on the left side. The patient remains disease-free six months post-op. She uses a bone-conduction hearing aid to good effect on the right side and has mild hearing loss on the left. The operative areas have healed well. DISCUSSION: The patient's previous radiotherapy and immunosuppression may have contributed to her bilateral external auditory canal squamous cell carcinoma. Preventative positron emission tomography scans have the potential to identify second malignancies early, allowing more conservative treatment plans.

Indexed as

carcinomaEar canalhearing lossimmunosuppression therapyintensity-modulatedneoplasmsradiotherapysecond primarysquamous cell

Identifiers

PMID40552591
PMCPMC12558706

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.