ArticleJournal of neuroscience research2025
Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation.
Article in Journal of neuroscience research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Physiological predictors of exercise-induced increases in circulating BDNF isoforms and net cerebral lactate exchange in healthy adults.Frontiers in physiology · 2026Article
- Walking handball as an exercise alternative to conventional walking and recreational team handball.Frontiers in sports and active living · 2026Article
- Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation.Journal of neuroscience research · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The aim of this study was to determine the relationship between BDNF and lactate concentration, accounting for genotype and sex, before and after a submaximal graded exercise test in 31 adults (37.5 ± 14.0 years, 54.8% female). The presence of the Val66Met polymorphism was identified at baseline, and BDNF and lactate concentrations were measured before and after exercise. Pearson's correlation coefficient was used to determine the relationship between BDNF and lactate concentration at pre- and post-exercise, and change in concentration (post- minus pre-exercise). The Val66Met polymorphism was identified in 11 participants (35%, seven females). An increase in BDNF and lactate concentration was observed from pre- to post-exercise (p < 0.001), but no significant correlation between the two measures was observed at pre-exercise (r = -0.256, p = 0.164), post-exercise (r = 0.112, p = 0.549), and change in concentration (r = 0.019, p = 0.921). A moderate inverse correlation was observed in participants with the Val66Met polymorphism (r = -0.744, p = 0.009) and males (r = -0.695, p = 0.006) at pre-exercise. The results show that while BDNF and lactate concentrations increased following a submaximal graded exercise test, there is little evidence to suggest a relationship exists between BDNF and lactate.
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Registered trials
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