ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Baicalin alleviates mastitis in dairy cows by targeting IL-17RA to inhibit IL-17 signaling pathway activation.Journal of animal science and biotechnology · 2026Article
- Cyanidin-3-O-galactoside improves meat quality, flavor and health attributes in small-tailed han lambs.NPJ science of food · 2026Article
- Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress viaMaterials today. Bio · 2025Article
- Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
24 authors.
Funding
Abstract
Mastitis poses a huge economic burden, with antibiotics treatment leading to drug residues and the emergence of bacterial resistance. Therefore, there is an urgent need to develop alternatives to antibiotics for the treatment of mastitis. Anthocyanins (ACN) have excellent anti-inflammatory properties. However, the key pathways of mastitis disease progression and the therapeutic effects of ACN on mastitis remain poorly understood. In this study, using cows, goats, and mice as animal models, the efficacy of ACN extracts from crabapple fruit is investigated in alleviating the severity of mastitis and blood milk barrier (BMB) damage. A monomeric component, cyanidin 3-O-galactoside (C3Gal) is identified, that exhibited considerable effect on mastitis. Mechanistically, C3Gal regulated mastitis progression by inhibiting PANoptosis activation, and suppressing gasdermin D N-terminal activity to regulate BMB damage during mastitis. These findings establish PANoptosis as a critical pathway in the rapid progression of mastitis and highlight the potential of ACN extracts as effective alternatives to antibiotic for mastitis treatment. This study provides a promising strategy for the discovery and application of drugs for the treatment of inflammatory diseases, expands the application of ACN in inflammatory diseases, and elucidates the molecular mechanisms underlying its anti-inflammatory effect.
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Registered trials
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