ArticleFood science & nutrition2025
Threshold Effects of Third-Trimester Maternal Vitamin A on Neonatal Ponderal Index: A Segmented Regression Analysis of 442 Mother-Infant Pairs.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Threshold Effects of Third-Trimester Maternal Vitamin A on Neonatal Ponderal Index: A Segmented Regression Analysis of 442 Mother-Infant Pairs.Food science & nutrition · 2025Article
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4 authors.
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Abstract
The significance of vitamin A during pregnancy for fetal growth and development has garnered increasing attention. However, the dose-response relationship between vitamin A concentration in late pregnancy and the offspring's ponderal index (PI) remains unclear. This study aims to investigate this relationship and determine the optimal supplementation level of vitamin A, providing a scientific basis for clinical nutritional interventions. This study selected pregnant women and their offspring who voluntarily participated and established records at the Obstetrics Department of Shandong Second Medical University Affiliated Hospital from March 1, 2023, to September 1, 2024. A self-designed questionnaire was utilized to collect demographic characteristics of the pregnant women, as well as factors influencing offspring growth. Fasting venous blood samples were collected from the pregnant women during late pregnancy (28 to 40 weeks), and high-performance liquid chromatography (HPLC) was employed to measure serum concentrations of vitamins A, E, and C. Standard physical measurement methods were used to assess the offspring's birth weight and length. Data analysis was conducted using R programming language and EmpowerStats software, employing segmented linear regression analysis to determine the threshold of vitamin A concentration and its impact on PI. Analysis of 442 mother-infant pairs showed a nonlinear relationship between maternal vitamin A levels in the third trimester and the neonatal ponderal index (PI). An inverted U-shaped curve was observed, with two key inflection points at 0.65 μmol/L (lower threshold) and 1.65 μmol/L (upper threshold). Within the optimal range of 0.65 to 1.65 μmol/L, each 0.5 μmol/L increase in vitamin A raised PI by 0.47 kg/m
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