ArticleFood science & nutrition2025
Genetically Predicted Gut Microbiota and Host Metabolites Mediate the Causal Link Between Dietary Factors and Acute Myeloid Leukemia.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Cholesterol Reprogramming in Acute Myeloid Leukemia: Integrating Tumor-Intrinsic Metabolism and Immune Crosstalk.Diseases (Basel, Switzerland) · 2026Review
- Causal effects of gut microbiota and blood metabolites on subtypes of perinatal depression classified based on depressive symptom trajectories: a mendelian randomization study.Nutrition & metabolism · 2026Article
- Therapeutic ecology of the fiber-microbiota-barrier axis in leukemia: resilience, immune recovery and pharmacomicrobiomics.Frontiers in microbiology · 2026Review
- Genetically Predicted Gut Microbiota and Host Metabolites Mediate the Causal Link Between Dietary Factors and Acute Myeloid Leukemia.Food science & nutrition · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary factors may have a causative influence on acute myeloid leukemia (AML), a hematologic cancer known to be highly fatal. It is still mostly unknown whether causal mechanisms connect dietary exposures to AML, particularly through the gut microbiota and host metabolism. A two-sample Mendelian randomization (MR) analysis was conducted using genome-wide association study (GWAS) data to assess the causal effect of 20 routine dietary factors on AML. A two-step MR framework was employed to assess the mediating roles of gut microbiota and host metabolites. Sensitivity analyses, including inverse variance weighted (IVW), MR-Egger, and MR-PRESSO, were performed to ensure the robustness of results. Processed meat consumption was causally associated with an increased risk of AML (IVW OR = 15.111; 95% CI = 1.253-182.262;
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Registered trials
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