Evidence map›Paper›PMID 40552282›Full record

ArticleFrontiers in immunology2025

Itaconate and obesity-related hormones promote tumor progression - new insights on metabolic dysfunction in early-onset colon cancer.

Katharina M Scheurlen, Jacob Hallion, Dylan L Snook, Anne MacLeod, Robert J Beal, Mary A Parks, Andrew B Littlefield, Eliah Hiken, Adrian T Billeter, Jeannette Bensen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Role of itaconate in intestinal disease (Review).International journal of molecular medicine · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katharina M ScheurlenDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Jacob HallionDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Dylan L SnookDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Anne MacLeodDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Robert J BealDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Mary A ParksDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Andrew B LittlefieldDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Eliah HikenDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.
Adrian T BilleterDepartment of Visceral Surgery, Clarunis-University Digestive Healthcare Center, St. Claraspital and University Hospital Basel, Basel, Switzerland.
Jeannette BensenLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jeremy T GaskinsDepartment of Bioinformatics & Biostatistics, University of Louisville, Louisville, KY, United States.
Julia CharikerKentucky IDeA Networks of Biomedical Research Excellence (KY INBRE), Bioinformatics Core, University of Louisville, Louisville, KY, United States.
Eric C RouchkaKentucky IDeA Networks of Biomedical Research Excellence (KY INBRE), Bioinformatics Core, University of Louisville, Louisville, KY, United States.
Susan GalandiukDigestive Surgery Research Laboratory, Price Institute of Surgical Research, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville, Louisville, KY, United States.

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
NIGMS NIH HHS P20 GM103436
6 · The paper itself

Abstract

Introduction: Obesity is a strong risk factor for early-onset colon cancer (EOCC) and is associated with chronic inflammation largely mediated by macrophages. The macrophage-specific metabolite itaconate promotes growth in several types of cancer; however, its role in colon cancer (CC) is unknown. Here, we investigate a tumor promoting link between obesity-related hormones and itaconate within the NOTCH4-GATA4-IRG1 pathway in EOCC. Methods: Patient tissue (n=20) was obtained and qRT-PCR, ELISA, and mass spectrometry were performed to evaluate Results: Both ACOD1 and Discussion: Obesity-related hormones can increase itaconate production in M2-like macrophages.

Indexed as

Colonic NeoplasmsObesitySuccinatesAgedCarboxy-LyasesCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansLeptinMacrophagesMaleMiddle AgedSignal TransductionACOD1 protein, humanCarboxy-Lyasesitaconic acidLeptinSuccinatesearly-onset colon cancerimmunologymacrophagesmetabolismobesity

Identifiers

PMID40552282
PMCPMC12183228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.