ArticleThe annals of applied statistics2021
CAUSAL MEDIATION ANALYSIS FOR SPARSE AND IRREGULAR LONGITUDINAL DATA.
Article in The annals of applied statistics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Causal functional mediation analysis with an application to functional magnetic resonance imaging data.Biostatistics (Oxford, England) · 2025Article
- Mediation analysis with graph mediator.Biostatistics (Oxford, England) · 2025Article
- Examining the interconnections among income, food prices, food insecurity, and health expenditure: a multicausality approach.BMC public health · 2025Article
- Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD.bioRxiv : the preprint server for biology · 2025Article
- Practical challenges in mediation analysis: a guide for applied researchers.Health services & outcomes research methodology · 2025Article
- Mediation Analysis with Multiple Exposures and Multiple Mediators.Statistics in medicine · 2024Article
- INTEGRATING INCOMPLETE DATA FOR MEDIATION ANALYSIS.Statistica Sinica · 2024Article
- Causal mediation analysis using high-dimensional image mediator bounded in irregular domain with an application to breast cancer.Biometrics · 2023Article
- Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count.Schizophrenia (Heidelberg, Germany) · 2023Article
- Social and early life determinants of survival from cradle to grave: A case study in wild baboons.Neuroscience and biobehavioral reviews · 2023Review
- A Causal Mediation Model for Longitudinal Mediators and Survival Outcomes with an Application to Animal Behavior.Journal of agricultural, biological, and environmental statistics · 2023Article
- Early life adversity and adult social relationships have independent effects on survival in a wild primate.Science advances · 2023Article
- CAUSAL MEDIATION ANALYSIS FOR SPARSE AND IRREGULAR LONGITUDINAL DATA.The annals of applied statistics · 2021Article
- Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A Causal Approach to Functional Mediation Analysis with Application to a Smoking Cessation Intervention.Multivariate behavioral researchArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Causal mediation analysis seeks to investigate how the treatment effect of an exposure on outcomes is mediated through intermediate variables. Although many applications involve longitudinal data, the existing methods are not directly applicable to settings where the mediator and outcome are measured on sparse and irregular time grids. We extend the existing causal mediation framework from a functional data analysis perspective, viewing the sparse and irregular longitudinal data as realizations of underlying smooth stochastic processes. We define causal estimands of direct and indirect effects accordingly and provide corresponding identification assumptions. For estimation and inference, we employ a functional principal component analysis approach for dimension reduction and use the first few functional principal components instead of the whole trajectories in the structural equation models. We adopt the Bayesian paradigm to accurately quantify the uncertainties. The operating characteristics of the proposed methods are examined via simulations. We apply the proposed methods to a longitudinal data set from a wild baboon population in Kenya to investigate the causal relationships between early adversity, strength of social bonds between animals and adult glucocorticoid hormone concentrations. We find that early adversity has a significant direct effect (a 9-14% increase) on females' glucocorticoid concentrations across adulthood but find little evidence that these effects were mediated by weak social bonds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.