Evidence map›Paper›PMID 40552248›Full record

ReviewCurrent ophthalmology reports2025

Subepithelial Lesions of the Ocular Surface: A Review.

Wisam Najdawi, Wendy J Li, Sofia De Arrigunaga, Mona M Amer, Anat Galor, Carol L Karp

Abstract readReview
In one paragraph

Review in Current ophthalmology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Review of the Use of Artificial Intelligence in Ophthalmology Imaging: Approximation to Ocular Histopathology.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wisam NajdawiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.
Wendy J LiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.
Sofia De ArrigunagaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.
Mona M AmerDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.
Anat GalorDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.
Carol L KarpDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL 33136 USA.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Tear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0M
BLRD VA I01 BX004893CSRD VA I01 CX002015NEI NIH HHS P30 EY014801NEI NIH HHS R61 EY032468
6 · The paper itself

Abstract

Purpose of Review: Subepithelial lesions of the ocular surface represent a diverse group of pathologies which may be difficult to diagnose clinically. Some of these lesions are relatively uncommon, may result in systemic manifestations, or occur secondary to systemic disease. The purpose of this review is to summarize current approaches to the diagnosis and management of six subepithelial conjunctival lesions. Recent Findings: The standard for the diagnosis of subconjunctival lesions remains histopathologic evaluation; however, high-resolution anterior segment optical coherence tomography (HR-OCT) is a useful supplemental diagnostic tool that may facilitate diagnosis. Recent advancements in the management of subconjunctival lesions include targeted systemic therapies in conjunctival melanoma and ultra-low dose radiation radiotherapy in conjunctival lymphoma. Summary: The development of HR-OCT has provided clinicians with valuable supplemental diagnostic information to guide the diagnosis of subepithelial lesions. Additionally, novel treatment modalities may provide an alternative to traditional surgical interventions in some pathologies.

Indexed as

Benign reactive lymphoid hyperplasiaConjunctival amyloidosisConjunctival lymphomaConjunctival melanomaConjunctival myxomaConjunctival neuromaHigh-resolution optical coherence tomography

Identifiers

PMID40552248
PMCPMC12182479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.