ArticleFrontiers in public health2025
Reducible burden of laryngeal cancer in men aged 50 and older attributable to smoking and alcohol use: insights from the global burden of disease study 2021.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Smoking, alcohol use, advanced age, and male gender are well-established risk factors for laryngeal cancer. As smoking and alcohol consumption are modifiable behaviors, the burden of laryngeal cancer attributable to these factors is potentially reducible. This study aims to quantify the global, regional and national burden of laryngeal cancer attributable to smoking and alcohol use in men aged 50 years and older, assess temporal trends from 1990 to 2021, and project the disease burden through 2040. Methods: The burden of laryngeal cancer was assessed using data from the Global Burden of Disease 2021, including deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs). The estimated average percentage change (EAPC) was used to evaluate trends in the disease burden from 1990 to 2021. Finally, projections for 2040 were generated and calculated with Nordpred. Results: From 1990 to 2021, globally, the absolute burden of laryngeal cancer-measured by deaths, DALYs, YLLs, and YLDs-attributable to smoking and alcohol use increased among men aged 50 years and older, despite declining age-standardized rates (ASRs). Regionally, Central and Eastern Europe experienced the highest burden, which may be attributed to historically elevated rates of smoking and alcohol consumption in these regions. Countries with the greatest disease burden related to smoking at the national level include Cuba, Montenegro, Seychelles, Georgia, and Monaco, while Montenegro, Bulgaria, Romania, and Monaco have the highest alcohol-related burden. By 2040, the overall burden is projected to rise. Conclusion: Smoking and alcohol-related laryngeal cancer will pose a significant public health challenge in the future. As the aging demographic continues to grow, the disease burden among older adult men is expected to rise. There are notable regional and national differences in terms of deaths, DALYs, YLLs, and YLDs. To address the rising burden, targeted public health actions are urgently required. These include higher taxation on tobacco and alcohol, comprehensive bans on related advertising, stricter enforcement of sales and age restrictions, enhanced health education regarding their health risks, and strengthened efforts in early screening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.