Evidence map›Paper›PMID 40552132›Full record

ArticleBlood neoplasia2024

BIRC5 upregulation enhances DNMT3A-mutant T-ALL cell survival and pathogenesis.

Wangisa Dunuwille, William C Wilson, Hassan Bjeije, Nancy Issa, Wentao Han, Tyler M Parsons, Andrew L Young, Infencia Xavier Raj, Aishwarya Krishnan, Tarang Gaur and 7 more

Abstract read
In one paragraph

Article in Blood neoplasia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wangisa DunuwilleDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
William C WilsonDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Hassan BjeijeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Nancy IssaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Wentao HanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Tyler M ParsonsDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Andrew L YoungDivision of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Infencia Xavier RajDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Aishwarya KrishnanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Tarang GaurDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Eunice S WangDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
Andrew P WengDepartment of Pathology and Laboratory Medicine, Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada.
Matthew C StubbsMyeloid Biology Group, Incyte Research Institute, Wilmington, DE.
Hamza CelikMyeloid Biology Group, Incyte Research Institute, Wilmington, DE.
Amanda F CashenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
John R EdwardsDepartment of Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO.
Grant A ChallenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm. Although the prognosis of pediatric T-ALL has improved with intensified chemotherapy regimens, this benefit has largely not translated to the adult T-ALL population. Development of new treatments requires understanding the mechanisms driven by specific mutations.

Identifiers

PMID40552132
PMCPMC12182843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.