Evidence map›Paper›PMID 40552118›Full record

ArticleFrontiers in cellular and infection microbiology2025

Lower respiratory tract co-infection of

Xiaoran Yu, Xuemei Yang, Yiqin Song, Jie Yu, Tingting Jiang, He Tang, Xiaoxuan Yang, Xi Zeng, Jing Bi, Adong Shen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoran Yu *Laboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.
Xuemei Yang *Laboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.
Yiqin Song *Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
Jie YuLaboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.
Tingting JiangBaoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
He TangBaoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
Xiaoxuan YangBaoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
Xi ZengLaboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.
Jing BiBaoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
Adong ShenLaboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.
Lin SunLaboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lower respiratory tract infections (LRTI), which are most commonly caused by Methods: A population-based cross-sectional study was conducted on children aged 0-18 years who were admitted to Beijing Children's Hospital and Baoding Children's Hospital in China from September 2021 to August 2022. Children with LRTI who underwent respiratory pathogen testing were divided into SP single infection and SP-RSV co-infection groups, with sex- and time-matched non-LRTI children as controls. Sputum and LRT secretion samples were collected for microbiota analysis using 16S rRNA sequencing, and child characteristics were obtained from medical records and pharmacy data. Results: A total of 125 children with LRTI (84 with SP infection and 41 with SP-RSV co-infection) and 87 children without LRTI were recruited for this study. We found that LRT microbiota composition was strongly related to age, with a more pronounced increase in Shannon index within the first 5 years of life. Children with SP and RSV infection exhibited significantly altered microbiota composition in comparison to children without LRTI, particularly a higher abundance of Conclusion: Our findings show that RSV co-infection exacerbates SP-induced LRTI microbiota disorder and disease severity. This study may help us to better understand the characteristics of SP-RSV interaction and provide direction for the pathogen diagnosis of LRTI.

Indexed as

CoinfectionPneumococcal InfectionsRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsStreptococcus pneumoniaeAdolescentChildChild, PreschoolChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleMicrobiotaRNA, Ribosomal, 16Schildrenlower respiratory tract infectionsmicrobiotarespiratory syncytial virusStreptococcus pneumoniae

Identifiers

PMID40552118
PMCPMC12183261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.