Evidence map›Paper›PMID 40552112›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Injectable ion-coordinated double-network conductive hydrogel for spinal cord injury repair.

Huan Yu, Fan Liu, Yaorui Hu, Weikang Wan, Qing Liu, Shuai Zhou, Luping Zhang, Liming Li, Fei Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huan Yu *School of Special Education and Rehabilitation, Binzhou Medical University, Yantai, China.
Fan Liu *School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Yaorui HuDepartment of Anatomy, School of Basic Medicine, Shandong University, Jinan, Shandong, China.
Weikang WanSchool of Special Education and Rehabilitation, Binzhou Medical University, Yantai, China.
Qing LiuDepartment of Anatomy, School of Basic Medicine, Shandong University, Jinan, Shandong, China.
Shuai ZhouInstitute of Neurobiology, Binzhou Medical University, Yantai, China.
Luping ZhangInstitute of Neurobiology, Binzhou Medical University, Yantai, China.
Liming LiSchool of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, China.
Fei HuangInstitute of Neurobiology, Binzhou Medical University, Yantai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mammalian central nervous system (CNS) demonstrates a severely limited capacity for spontaneous neural regeneration after traumatic spinal cord injury (SCI). Structural repair is also highly constrained due to the inhibitory microenvironment. This inherent limitation persists throughout the recovery phase and often leads to severe motor and sensory dysfunction, profoundly impairing patients' quality of life. Current clinical treatments, including surgical decompression, pharmacological interventions, and rehabilitation therapy, can only partially relieve symptoms. They are not enough to promote neural regeneration and functional recovery. There is an urgent need to develop novel therapeutic approaches to overcome this challenge. This study developed and created an injectable double-network conductive hydrogel, it coordinates iron ions (Fe

Indexed as

double-network hydrogelinjectable hydrogeliron ion (Fe3+) coordinationneural repairspinal cord injury

Identifiers

PMID40552112
PMCPMC12183279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.