Evidence map›Paper›PMID 40552084›Full record

ReviewFrontiers in toxicology2025

Cannabis concentrate vaping chemistry.

Kaelas R Munger, Killian M Anreise, Robert M Strongin

Abstract readReview
In one paragraph

Review in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Vaping ΔExpert review of clinical pharmacology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kaelas R MungerDepartment of Chemistry, Portland State University, Portland, OR, United States.
Killian M AnreiseDepartment of Chemistry, Portland State University, Portland, OR, United States.
Robert M StronginDepartment of Chemistry, Portland State University, Portland, OR, United States.

Funding

Emerging Trends in the Chemistry of Cannabis Vaping and Toxicant EmissionsR16DA061946 · NIDA · PORTLAND STATE UNIVERSITY · PI ROBERT M STRONGIN · 2024 to 2026
$423k
NIDA NIH HHS R16 DA061946
6 · The paper itself

Abstract

Background: This review article addresses the vaping chemistry of manufactured cannabis concentrates-a topic that remains under-researched despite the widespread availability and growing popularity of these products. Given their current prevalence and the fact that many of the findings discussed herein are from early-stage investigations, further research is essential to fully assess the public health risks associated with concentrate use. The purpose of this article is to help begin to bridge this knowledge gap by outlining the technical challenges of studying cannabis concentrates and to present evidence-based data concerning toxicant exposures as a foundation for future investigations. Methods: A search of cannabis concentrate vaping within the date range of 2019-2025 on Google Scholar returned approximately 2,700 hits. A cannabis concentrate was defined as a sample containing at least 50% (w/w) cannabinoids. In addition to our group's articles, the search results contained six manuscripts that described at least a partial focus on molecular emissions specifically derived from vaping or dabbing samples that included cannabis concentrates. Findings: Studying cannabis concentrate vaping poses distinct technical challenges that differ from those associated with electronic nicotine delivery systems. Emissions from vaping concentrates contain a substantial proportion of harmful aerosol toxicants, including isoprene, 3-methylcrotonaldehyde, 3-methyl-1-butene, and 2-methyl-2-butene. Moreover, some concentrate formulations have contained hazardous additives such as pine rosin and ketene precursors such as cannabinoid acetates. As with nicotine vaping, the presence of oxygen plays a critical role in driving the formation of many toxic chemical degradation products during vaping. Conclusion: Since the legalization of recreational cannabis, concentrates have become one of the most rapidly expanding segments of the U.S. cannabis market. However, research into the specific health risks of vaping these products has significantly lagged their widespread use. The studies presented in this review article highlight the potential for exposure to known toxicants during the vaping of cannabis concentrates.

Indexed as

cannabis concentratescannabis vapingdabbingketenepine rosinterpenesterpene vapingvaping

Identifiers

PMID40552084
PMCPMC12183170

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.