ArticleFrontiers in veterinary science2025
Integrated multi-omics analysis reveals that Gongying San ameliorates subclinical mastitis by modulating intestinal microbiota and metabolites in dairy cows.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Integrative multi-omics analysis identifies C-type lectin CNVs as functional targets for breeding mastitis-resistant dairy goats.Animal microbiome · 2026Article
- Effects of Replacing Soybean Meal with Different Proportions of Black Soldier Fly Larvae Meal on Antioxidant Indicators, Immune System, and Gut Health of Xichuan Black-Bone Chickens.Antioxidants (Basel, Switzerland) · 2026Article
- Knockout of theVeterinary sciences · 2026Article
- Multi-Omics Analyses Reveal the Antifungal Mechanism of Phenazine-1-Carboxylic Acid AgainstJournal of fungi (Basel, Switzerland) · 2025Article
- Targeting the Gut-Mammary Axis for Understanding Mastitis Pathogenesis and Therapeutic Strategies.Veterinary sciences · 2025Review
- Isolation, identification, and susceptibility testing ofFrontiers in veterinary science · 2025Article
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Authors and funding
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Abstract
Introduction: Subclinical mastitis (SCM) is a common disease in dairy cows associated with dysbiosis of the gastrointestinal microbiota and systemic inflammatory response. Gongying San (GYS), a commonly used herbal formula for the treatment of mastitis, has anti-inflammatory, antibacterial and antioxidant effects, but the underlying mechanisms remain unknown. Therefore, we performed a multi-omics analysis to determine the effects of GYS on intestinal microbiota and metabolites in cows with SCM. Methods: A total of 32 Holstein cows were divided into four groups of 8 cows each, including healthy control group, subclinical mastitis group, GYS treatment group (290 g/day) and ceftiofur treatment group (2.2 mg/kg bw). Results: GYS significantly increased milk yield, lactose and milk protein, and decreased somatic cell count (SCC) in milk from cows with SCM. In the serum, GYS decreased the levels of lipopolysaccharide (LPS), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA) and increased the concentration of superoxide dismutase (SOD). In addition, there was an increase in Discussion: In the treatment of SCM, GYS showed multi-target therapeutic advantages of anti-inflammatory, antioxidant and immunomodulatory properties compared to antibiotics.
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