ArticleFrontiers in veterinary science2025
Effects of chicken hemoglobin antimicrobial peptides on intestinal mucosal immunity under chronic heat stress and vaccination responses in broilers.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Synergies and Trade-Offs in Modern Poultry Nutrition: An Integrated Framework Linking Animal Health, Productivity and Greenhouse Gas Mitigation.Veterinary sciences · 2026Review
- Total saponins of Gynostemma pentaphyllum mitigate chronic heat stress-induced thymus and spleen inflammation in broilers via NF-κB pathway activation.Poultry science · 2026Article
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Authors and funding
5 authors.
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Abstract
Heat stress (HS) is a major concern in poultry production worldwide due to its adverse effects on feed intake, weight gain, carcass weight, and metabolic conditions. Several strategies have been explored to ameliorate the negative effects of HS in broiler chickens, among which antimicrobial peptides (AMPs) represent a promising approach. Previously, we isolated chicken hemoglobin antimicrobial peptides (CHAP) and further demonstrated that CHAP has strong bactericidal activity. However, whether CHAP can improve growth performance and maintain intestinal mucosal immunity under chronic HS conditions remains unclear. In the present study, a total of 141 one-day-old broilers were divided into two groups. A total of 36 broilers were used to establish a chronic HS model to evaluate the effects of CHAP on intestinal mucosal immunity, and the remaining 105 birds were used to monitor the inductive effects of CHAP on two vaccines, including Newcastle disease virus (NDV) and avian influenza virus (AIV) vaccines, in broilers. As expected, HS-stimulated broiler chickens supplemented with CHAP showed a significant increase in villus height in the duodenum (
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