ArticleFrontiers in chemistry2025
HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation.
Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer and has shown a rising incidence globally. Despite its generally favorable prognosis, recurrence and therapeutic resistance remain challenges in clinical management. Traditional Chinese Medicine, particularly Xihuang Pill (XHP), has demonstrated promising anticancer potential in various tumors, but its molecular mechanisms in PTC remain unclear. This study aimed to explore the targets of XHP in the treatment of PTC. Methods: The active ingredients of XHP were first obtained, and ingredients and PTC-related targets were identified, followed by enrichment analysis. Protein-protein interaction (PPI) network was constructed to determine the key ingredients and targets, and then molecular docking was conducted. Key targets' prognostic role, correlation with differentiation, and immune infiltration level were analyzed based on the TCGA data. Results: Firstly, 132 common targets were associated with XHP and PTC, enriched in MAPK, PI3K-AKT, and HIF-1 signal pathways. Five hub genes (CCND1, ESR1, AKT, HIF-1A, BCL2) and 2 ingredients were found, with a favorable combination between them. AKT1 and HIF1A were upregulated in PTC, and high expressions of them were related to poor prognosis (all P < 0.05). Further, only HIF1A was upregulated in the advanced stage of PTC and significantly correlated with the dedifferentiation (all P < 0.05). HIF1A upregulation also correlated with the decrease of activated NK cells abundance in PTC (all P < 0.05), while NK cell abundance showed positive correlation with differentiation level (P < 0.05). HIF1A inhibited differentiation of PTC cells, while XHP suppressed PTC progression and promoted differentiation by downregulating HIF1A. Finally, histopathological type and positive lymph node number correlated with HIF1A expression (all P < 0.05). Conclusion: This study systematically elucidated the potential mechanisms by which XHP exerts anti-PTC effects, highlighting that HIF1A is a promising target of XHP in the treatment of PTC by regulating dedifferentiation. These findings provide a scientific basis for the application of XHP in PTC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.