Evidence map›Paper›PMID 40552024›Full record

ArticleJournal of veterinary research2025

Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes

Natalia Szysiak, Urszula Kosior-Korzecka, Monika Greguła-Kania, Krzysztof Patkowski, Mateusz Fila, Andrzej Junkuszew

Abstract read
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In one paragraph

Article in Journal of veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia SzysiakSub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland.
Urszula Kosior-KorzeckaSub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland.
Monika Greguła-KaniaDepartment of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950, Lublin, Poland.
Krzysztof PatkowskiDepartment of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950, Lublin, Poland.
Mateusz FilaSub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland.
Andrzej JunkuszewDepartment of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950, Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neurokinin B (NKB), dynorphin A (Dyn A) and kisspeptin (KiSS) are key agents that participate in the neuroendocrine regulation of the development and functioning of the reproductive system. While the role of KiSS is better understood, the functions of NKB and Dyn A at the pituitary level have not been elucidated. The objective of our study was to analyse their direct effect on kisspeptin-10 (KiSS-10) secretion by anterior pituitary cells isolated from pubescent ewes. Material and Methods: Pituitary cells from 10-month-old ewe lambs were incubated in McCoy's 5A medium without hormones (the control), or with 10 Results: When applied at the concentrations of 10 Conclusion: In contrast to Dyn A, NKB can directly affect KiSS-10 secretion from the pituitary cells of pubescent ewes in a way dependent on the time of exposure to this neuropeptide and its concentration in the culture medium. This phenomenon may indicate a potential role of NKB in the initiation of reproductive activity, which leads to the achievement of sexual maturity in the optimal developmental window.

Indexed as

dynorphin Akisspeptinneurokinin Bpituitarypuberty

Identifiers

PMID40552024
PMCPMC12182939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.