Evidence map›Paper›PMID 40551966›Full record

ArticleChemistrySelect2025

Single-Benzene-Based Clickable Fluorophores for In Vitro and In Vivo Bioimaging.

Raja Mohanrao, Clyde S Pinto, Andrejus Suchenko, Guy J Clarkson, Martin Wills, Stefan Roesner, Michael Shipman, Mohan K Balasubramanian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistrySelect, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raja MohanraoCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Science, University of Warwick, CoventryCV4 7AL, UK.
Clyde S PintoCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Science, University of Warwick, CoventryCV4 7AL, UK.
Andrejus SuchenkoCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Science, University of Warwick, CoventryCV4 7AL, UK.
Guy J ClarksonDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, UK.
Martin WillsDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, UK.
Stefan RoesnerDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, UK.
Michael ShipmanDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CoventryCV4 7AL, UK.
Mohan K BalasubramanianCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Science, University of Warwick, CoventryCV4 7AL, UK.

Funding

Wellcome Trust 101885Wellcome Trust 203276
6 · The paper itself

Abstract

A series of miniaturized, clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile is reported. Fluorophores based on a tetrahydroquinoxaline skeleton exhibited improved photophysical properties due to enhanced electron delocalization between donor and acceptor groups compared to those with a dihydro[1,4]thiazine skeleton. These easily synthesized clickable fluorophores were successfully applied in both in vitro and in vivo bioimaging following protein conjugation.

Indexed as

BioconjugatesBioimagingChromophoresFluorescent probesSingle-benzene fluorophores

Identifiers

PMID40551966
PMCPMC7617796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.