ArticleCureus2025
Prevalence and Clinical Correlates of Hypomagnesemia in Ischemic Stroke Patients: A Single-Center Study From a Tertiary Care Center in Pakistan.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHypomagnesemia has been linked to stroke development through its effects on blood vessel function and nerve cell excitability, but data from South Asia are limited. The aim of this study was to determine the prevalence of hypomagnesemia in patients with acute ischemic stroke and its associated risk factors at a tertiary care hospital in Pakistan.
methodsThe study employed a cross-sectional design, conducted from November 2020 to June 2021, and enrolled 137 consecutive stroke patients. Hypomagnesemia was defined as serum magnesium levels less than 1.82 mg/dL. SPSS software v24 (IBM Corp., Armonk, NY) was used to analyze the association between hypomagnesemia and various demographic and clinical factors.
resultsHypomagnesemia was found to be present in 48.9% of ischemic stroke patients. The most common associated comorbidities were hypertension and type 2 diabetes mellitus. The study discovered a strong correlation between hypertension and stroke, and 61.1% of the hypertensive patients with stroke had hypomagnesemia. Hypomagnesemia was found in 18.5% of smokers compared to 56.4% of non-smokers, indicating an inverse connection with smoking. The prevalence of hypomagnesemia was similar in males and females and across age groups.
conclusionHypomagnesemia was present in nearly half of the patients with acute ischemic stroke, and hypertension was a strong predictor. Further study is warranted for the lower prevalence of hypomagnesemia among smokers. Secondary strokes may be prevented in high-risk individuals by routine magnesium screening and supplementation.
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