Evidence map›Paper›PMID 40551866›Full record

ArticleHealth science reports2025

Enhancing Emergency Preparedness: A Call to Incorporate Postexposure Prophylaxis in Mass Casualty Protocols.

Majani Edward, Archie Hellar, Chizaram Onyeaghala, Oluruntoba Ogunfolaji

Abstract read
In one paragraph

Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Majani EdwardDepartment of Public Health St. Francis University College of Health and Allied Sciences Ifakara Tanzania.ORCID https://orcid.org/0000-0002-1671-9584
Archie HellarDepartment of Public Health St. Francis University College of Health and Allied Sciences Ifakara Tanzania.
Chizaram OnyeaghalaUniversity of Port Harcourt Hospital Port Harcourt Nigeria.
Oluruntoba OgunfolajiResearch Department Association of Future African Neurosurgeons Yaounde Cameroon.ORCID https://orcid.org/0000-0002-4201-9127

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Mass casualty incidents (MCIs) present significant challenges to emergency response systems, often overwhelming healthcare resources. This article highlights the critical role of integrating postexposure prophylaxis (PEP) into emergency protocols to mitigate immediate and secondary health risks occurring due to mass casualty. The aim is to underscore the importance of PEP in MCI management and advocate for its systematic incorporation into emergency preparedness and response. Methods: This is a perspective article drawing upon existing literature, guidelines from organizations such as UNAIDS, and expert opinion to synthesize the importance of PEP in the context of MCIs. It discusses the rationale for PEP, challenges in its implementation, particularly in resource-limited settings, and proposes strategies for its integration into emergency protocols. Results: The analysis underscores that prompt PEP administration significantly reduces the risk of bloodborne pathogen transmission following potential exposure during MCIs. Effective MCI response necessitates hospital preparedness, robust Emergency Medical Services (EMS), interagency collaboration, and trained personnel. The potential for HIV transmission in crash emergencies is often overlooked, highlighting the urgent need for PEP inclusion in emergency protocols. Key recommendations include establishing robust surveillance systems, training first responders, ensuring the availability of personal protective equipment and point-of-care test kits, establishing blood bank networks, and ensuring widespread access to PEP with a low threshold for its administration. Conclusion: Integrating PEP into emergency response strategies is imperative for enhancing the resilience and preparedness of healthcare systems, especially in resource-constrained settings. This proactive approach can significantly reduce morbidity, mortality, and the public health burden associated with infectious disease transmission following MCIs. Therefore, the systematic incorporation of PEP into emergency protocols, supported by interagency collaboration, training, and resource allocation, is strongly recommended.

Indexed as

HIVmass casualtyPEP

Identifiers

PMID40551866
PMCPMC12183375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.