ArticleERJ open research2025
Impact of positive airway pressure on right ventricular afterload in pulmonary arterial hypertension.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Heart-Lung Interactions in Combined Distributive Shock and ARDS: Applied Cardiopulmonary Physiology at the Bedside.Journal of clinical medicine · 2025Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale: The impact of continuous positive airway pressure (CPAP) is currently unknown in patients with pulmonary arterial hypertension (PAH). The objective of the present study was to investigate the effect of CPAP on cardiopulmonary haemodynamics in patients with PAH compared to healthy volunteers. Methods: All participants underwent an oesophageal catheter insertion followed by right heart catheterisation with and without the application of CPAP at 10 cmH Results: In both PAH (n=18) and healthy (n=5) participants the acute application of CPAP increased the oesophageal pressure significantly from baseline (all p<0.007). There was a decline in cardiac output in both groups from baseline (p=0.047), which was due to a reduction in heart rate (p=0.027) rather than stroke volume (p=0.8). CPAP significantly reduced right ventricular end-diastolic pressure (p=0.02), without a significant impact on resistive right ventricular afterload. CPAP did not significantly change pulmonary artery or pulmonary vascular resistance in either group. The calculated dynamic pulmonary arterial compliance was increased in both groups. Conclusions: In PAH and healthy participants, CPAP had a modest effect on intrapleural pressures. The transmural haemodynamic changes of CPAP were modest with a net increase in pulmonary vascular compliance in both groups, but no change in resistive right ventricular afterload in the PAH group. The current study did not demonstrate any deleterious effects of CPAP on pulmonary haemodynamics.
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Registered trials
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