Evidence map›Paper›PMID 40551797›Full record

ArticleERJ open research2025

Natural variability of lung function in primary ciliary dyskinesia: longitudinal analysis from the PROVALF-PCD cohort.

Kewei Zhang, Avni Kant, Mieke Boon, Melissa Borrelli, Carolina Constant, Silvia Castillo Corullon, Renato Cutrera, Stefanie Dillenhöfer, Sanem Eryılmaz Polat, Ela Eralp and 32 more

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Kewei ZhangClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.
Avni KantClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.
Mieke BoonDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Melissa BorrelliDepartment of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy.
Carolina ConstantDepartment of Pediatrics, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte and Faculty of Medicine, University of Lisbon, Lisbon, Portugal.ORCID https://orcid.org/0000-0002-6596-1596
Silvia Castillo CorullonFE Pediatría y Neumología Infantil, Unidad de Neumología Infantil y Fibrosis Quística, Hospital Clínico de Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0002-0121-2676
Renato CutreraRespiratory and Cystic Fibrosis Unit, Academic Pediatric Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0001-7711-5672
Stefanie DillenhöferDepartment of Paediatric Pulmonology, University Children's Hospital, Ruhr University Bochum, Katholisches Klinikum Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0001-6020-8717
Sanem Eryılmaz PolatHacettepe University Faculty of Medicine, Department of Pediatric Pulmonology, Ankara, Turkey.
Ela EralpMarmara Universitesi, Department of Pediatric Pulmonology, Istanbul, Turkey.
Nathalie FeyaertsDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Amanda HarrisClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.ORCID https://orcid.org/0000-0002-6953-7370
Claire HoggRoyal Brompton and Harefield NHS Foundation Trust, Department of Paediatrics, Primary Ciliary Dyskinesia Centre, London, UK.
Cordula Koerner-RettbergDepartment of Paediatric Pulmonology, University Children's Hospital, Ruhr University Bochum, Katholisches Klinikum Bochum, Bochum, Germany.
Panayiotis KouisMedical School, University of Cyprus, Nicosia, Cyprus.
Enrico LombardiMeyer Children's Hospital IRCCS, Florence, Italy.
Natalie LorentDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-2653-5885
June K MarthinDanish PCD and chILD Centre, CF Centre Copenhagen, Paediatric Pulmonary Service, ERN Accredited, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4420-3091
Vendula MartinuDepartment of Paediatrics, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.
Antonio Moreno-GaldoPaediatric Pulmonology Section, Department of Paediatrics, Hospital Universitari Vall dHebron, Barcelona, Spain.
Lucy MorganConcord Hospital, Concord Clinical School, University of Sydney, Department of Respiratory Medicine, Sydney, Australia.ORCID https://orcid.org/0000-0001-6389-1953
Kim NielsenDanish PCD and chILD Centre, CF Centre Copenhagen, Paediatric Pulmonary Service, ERN Accredited, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Heymut OmranDepartment of General Pediatrics, University Hospital Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0003-0282-6765
Ugur OzcelikHacettepe University Faculty of Medicine, Department of Pediatric Pulmonology, Ankara, Turkey.
Petr PohunekDepartment of Paediatrics, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.ORCID https://orcid.org/0000-0003-4557-2515
Phil RobinsonFaculty of Medicine Dentistry and Health Sciences, Paediatrics, University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0001-6129-9075
Sandra Rovira-AmigoPaediatric Pulmonology Section, Department of Paediatrics, Hospital Universitari Vall dHebron, Barcelona, Spain.ORCID https://orcid.org/0000-0001-9896-0621
Francesca SantamariaDepartment of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy.ORCID https://orcid.org/0000-0002-9375-7429
Anne SchlegtendalDepartment of Paediatric Pulmonology, University Children's Hospital, Ruhr University Bochum, Katholisches Klinikum Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0002-6737-3624
Aline TamaletSorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine, Paris, France.
Guillaume ThouveninSorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine, Paris, France.ORCID https://orcid.org/0000-0003-0528-5458
Dilber Ademhan TuralHacettepe University Faculty of Medicine, Department of Pediatric Pulmonology, Ankara, Turkey.
Nicola UllmannRespiratory and Cystic Fibrosis Unit, Academic Pediatric Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
Woolf T WalkerClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.
Panayiotis YiallourosMedical School, University of Cyprus, Nicosia, Cyprus.
Camille PearseMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Bettina FrauchigerDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Claudia E KuehniDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-8957-2002
Nicole BeydonAP-HP, Sorbonne Université, Unité d'Exploration Fonctionnelle Respiratoire, Hôpital Armand-Trousseau, and Sorbonne Université, INSERM U938, Paris, France.ORCID https://orcid.org/0000-0002-6417-382X
Philipp LatzinDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-5239-1571
Jane S LucasClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.ORCID https://orcid.org/0000-0001-8701-9975
Bruna RubboClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.ORCID https://orcid.org/0000-0002-1629-8601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The extent to which changes in lung function are due to natural variability in patients with primary ciliary dyskinesia (PCD) is unknown. We aimed to assess intra-individual variability in forced expiratory volume in 1 s (FEV Methods: PROVALF-PCD (Prospective Observational Multicentre Study on Variability of Lung Function in Stable PCD Patients) was a large international prospective cohort conducted in 2017-2019. We included patients aged ≥5 years who were clinically stable at two or more consecutive visits and provided spirometry-derived lung function measurements. To calculate the upper limit of normal (ULN), we fitted an unadjusted multilevel mixed-effect model, and to determine the absolute change in FEV Results: We included 252 participants from 12 countries with confirmed or highly likely PCD. We included 1028 FEV Conclusions: Changes in intra-individual FEV

Identifiers

PMID40551797
PMCPMC12183702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.