Evidence map›Paper›PMID 40551794›Full record

ArticleERJ open research2025

International consensus statement on routine blood testing in primary ciliary dyskinesia.

Sarah Altaraihi, June K Marthin, Pinelopi Anagnostopoulou, Mieke Boon, Siobhan B Carr, Silvia Castillo-Corullón, Eleonora Dehlink, Damien M S Destouches, Jamie Duckers, Eric G Haarman and 26 more

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nutrition and growth of primary ciliary dyskinesia patients: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Sarah AltaraihiDanish PCD Centre Copenhagen, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
June K MarthinDanish PCD Centre Copenhagen, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4420-3091
Pinelopi AnagnostopoulouMedical School, University of Cyprus, Nicosia, Cyprus.
Mieke BoonDepartment of Pediatrics, Pediatric Pulmonology, University Hospital Leuven, Belgium.
Siobhan B CarrRoyal Brompton Hospital and Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-0580-2478
Silvia Castillo-CorullónPediatric Pulmonology, Hospital Clinico de Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0002-0121-2676
Eleonora DehlinkDepartment of Paediatrics, Division of Paediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Vienna, Austria.
Damien M S DestouchesAssociation Dyskinésie Ciliaire Primitive, St Etienne, France.
Jamie DuckersUniversity Hospital Llandough, Cardiff and Vale University Health Board, Cardiff, UK.ORCID https://orcid.org/0000-0003-3004-279X
Eric G HaarmanDepartment of Pulmonary Medicine, Amsterdam University Medical Centre location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Bülent KaradagDivision of Pediatric Pulmonology, Marmara University, Istanbul, Turkey.
Christina KavouridouQueen Silvias Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Michael R LoebingerRoyal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
Bernard MaitreService de Pneumologie, Centre Hospitalier Intercommunal de Créteil, Unité de Pneumologie, GH Mondor, AP-HP, Créteil, France.
Henryk MazurekDepartment of Pneumonology and Cystic Fibrosis, National Tuberculosis and Lung Diseases Institute, Rabka Zdrój, Poland.
Lucy MorganMacquarie University Hospital, Sydney, Australia.ORCID https://orcid.org/0000-0001-6389-1953
Heymut OmranDepartment of General Paediatrics, University Children's Hospital Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0003-0282-6765
Ugur OzcelikDepartment of Pediatric Pulmonology, Hacettepe University Medical Faculty, Ankara, Turkiye.
Daniel PeckamLeeds Institute of Medical Research, University of Leeds, Leeds, UK.ORCID https://orcid.org/0000-0001-7723-1868
Massimo PifferiDepartment of Pediatrics, University Hospital of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-8266-1923
Petr PohunekPediatric Pulmonology, Pediatric Department, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.ORCID https://orcid.org/0000-0003-4557-2515
Tavs QvistDanish PCD Centre Copenhagen, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Johanna RaidtDepartment of General Paediatrics, University Children's Hospital Muenster, Muenster, Germany.
Phillipe ReixCentre de Référence des Maladies Respiratoires Rares de l'Enfant, Service de Pneumologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
Felix C RingshausenDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, and Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Center for Lung Research (DZL), Hannover, Germany.ORCID https://orcid.org/0000-0001-9084-4968
Phil RobinsonRespiratory Medicine, Royal Children's Hospital and University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0001-6129-9075
Evie RobsonNorth of England PCD Management Service, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Jobst RöhmelDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1535-8852
Francesca SantamariaDepartment of Translational Medical Sciences, Pediatric Pulmonology Unit, Federico II University, Naples, Italy.ORCID https://orcid.org/0000-0002-9375-7429
Anne SchlegtendalDepartment of Paediatric Pneumology, University Children's Hospital Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0002-6737-3624
Nicola UllmannPneumology and Cystic Fibrosis Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Woolf WalkerPrimary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Panayiotis YiallourosMedical School, University of Cyprus, Nicosia, Cyprus.
Guillaume ThouveninService de Pneumologie Pédiatrique, Hôpital Trousseau, AP-HP, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, Paris, France.ORCID https://orcid.org/0000-0003-0528-5458
Suzanne CrowleyPaediatric Department of Allergy and Lung Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway.ORCID https://orcid.org/0000-0003-2786-8718
Kim G NielsenDanish PCD Centre Copenhagen, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by dysfunction of motile cilia. Symptoms include recurrent and chronic airway infections which can lead to deteriorating lung function and inflammatory destructive lung disease in the form of persistent atelectasis and bronchiectasis. Routine blood testing may be used as a tool for disease monitoring and management. However, currently there are no consensus-based guidelines within the field of PCD. BEAT-PCD together with the ERN-LUNG PCD-Clinical Trial Network aimed to develop an international expert consensus statement on which routine blood tests should be conducted in patients with PCD. Methods: An international panel of 33 PCD experts from 17 countries was established to generate consensus on routine blood testing in PCD. A modified Delphi technique with three e-survey rounds was used to reach consensus, which was defined as ≥80% agreement for each statement. Two patient representatives were included in the consensus process. Results: The expert panel reached consensus on 51 out of 101 statements (50%) on routine blood testing in children and adults with PCD to be performed at diagnosis, annually and on exacerbation. The statements include biomarkers for inflammation, haemoglobin, iron status, vitamin D, immune function, inhalant allergies, liver and kidney function, and allergic bronchopulmonary aspergillosis. Conclusions: This is the first international consensus on routine blood testing in PCD. It highlights blood tests that may be relevant to perform at diagnosis, annually and on exacerbation in people with PCD. Further research on the clinical usefulness of routine blood testing in PCD is needed.

Identifiers

PMID40551794
PMCPMC12183740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.