Evidence map›Paper›PMID 40551787›Full record

ArticleERJ open research2025

Protein profiling in intensive care unit-treated COVID-19 patients identifies biomarkers of residual lung abnormalities.

Dimitrios Kalafatis, Mikael Björnson, Barbora Svobodová, Anna Kistner, Malin Nygren-Bonnier, Michael Runold, Judith Bruchfeld, Åsa Wheelock, Göran Dellgren, Linda Elowsson and 2 more

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dimitrios KalafatisLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0003-2917-5093
Mikael BjörnsonDivision of Infection Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Barbora SvobodováLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0001-5615-893X
Anna KistnerDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7942-3211
Malin Nygren-BonnierDivision of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Michael RunoldRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Judith BruchfeldDivision of Infection Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Åsa WheelockRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Göran DellgrenDepartment Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Linda ElowssonLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-0457-0188
Gunilla Westergren-ThorssonLung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Magnus SköldRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In this study, we combine proteomics with functional parameters and imaging to examine potential biomarkers that may identify patients at risk of developing persistent lung sequelae following coronavirus disease 2019 (COVID-19). Methods: We performed multiplex profiling of serum and collected clinical data from intensive care unit (ICU)-treated patients with COVID-19 (n=43) at 4 and 10 months post hospitalisation. Results: Four months post discharge, patients with COVID-19 demonstrated lower % predicted forced vital capacity (72.2% Conclusion: Despite functional and radiological improvements following COVID-19, persistent upregulation of inflammation and remodelling factors were observed. Similarities in the expression of LAMP3 in COVID-19 and idiopathic pulmonary fibrosis may suggest it as a potential biomarker for chronic lung damage.

Identifiers

PMID40551787
PMCPMC12183704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.