Evidence map›Paper›PMID 40551718›Full record

ArticleJournal of dietary supplements2025

Ashwagandha (

Kelli L McDonald, Zarna Raichura, Satyanarayana R Pondugula, Luke Marney, Liping Yang, Jaewoo Choi, Julia M Salamat, Mikah S Brandes, Cody Neff, Keila Adams and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dietary supplements, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Evaluation ofJournal of dietary supplements · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kelli L McDonaldDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.ORCID 0000-0002-0557-7509
Zarna RaichuraDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.ORCID 0000-0002-4447-4465
Satyanarayana R PondugulaDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
Luke MarneyDepartment of Chemistry, Oregon State University, Corvallis, OR, USA.
Liping YangDepartment of Chemistry, Oregon State University, Corvallis, OR, USA.
Jaewoo ChoiLinus Pauling Institute, Oregon State University, Corvallis, OR, USA.
Julia M SalamatDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
Mikah S BrandesBotanicals Enhancing Neurological and Functional Resilience in Aging (BENFRA) Botanical Dietary Supplements Research Center, Oregon Health and Science University, Portland, OR, USA.
Cody NeffBotanicals Enhancing Neurological and Functional Resilience in Aging (BENFRA) Botanical Dietary Supplements Research Center, Oregon Health and Science University, Portland, OR, USA.
Keila AdamsDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.
Gracie FarmerDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.
Catherine DennisDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.
Claudia S MaierDepartment of Chemistry, Oregon State University, Corvallis, OR, USA.
Amala SoumyanathBotanicals Enhancing Neurological and Functional Resilience in Aging (BENFRA) Botanical Dietary Supplements Research Center, Oregon Health and Science University, Portland, OR, USA.
Robert D ArnoldDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.ORCID 0000-0001-6143-3991
Angela I CalderónDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA.ORCID 0000-0003-0836-635X

Funding

Mechanisms underlying the cognitive effects of Centella asiatica water extract and constituent compounds in the 5xFAD mouse model of Alzheimer's DiseaseU19AT010829 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAIER, CLAUDIA S · 2020 to 2024
$6.1M
Ultra-Performance Liquid Chromatography Tandem Quadrupole Mass Spectrometry SystemS10OD026922 · OD · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S · 2019 to 2019
$577k
Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484k
Evaluation of the potential of Ashwagandha extracts to produce CYP-mediated drug interactions.R03AT011501 · NCCIH · AUBURN UNIVERSITY AT AUBURN · PI ARNOLD, ROBERT D · 2021 to 2022
$149k
NCCIH NIH HHS R03 AT011501NCCIH NIH HHS U19 AT010829NCRR NIH HHS S10 RR027878NIH HHS S10 OD026922
6 · The paper itself

Abstract

Ashwagandha (

Indexed as

Cytochrome P-450 Enzyme SystemHepatocytesPlant ExtractsWithaniaCells, CulturedCell SurvivalCytochrome P-450 CYP1A2Cytochrome P-450 CYP2B6Cytochrome P-450 CYP3AHep G2 CellsHerb-Drug InteractionsHumansPlant LeavesPlant RootsAshwagandhaCYP1A2 protein, humanCYP2B6 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP1A2Cytochrome P-450 CYP2B6Cytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemPlant ExtractsAshwagandhacytochrome P450 systemcytotoxicityhepatocytesplant extractsWithania

Identifiers

PMID40551718
PMCPMC12266684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.