Evidence map›Paper›PMID 40551712›Full record

ArticleActa biochimica et biophysica Sinica2025

Increased neutrophil senescence is associated with impaired immunosuppressive activity in systemic lupus erythematosus.

Lei Han, Fengling Huang, Qingchen Zhu, Huan Wang, Tianlin Lu, Chunyuan Xiao, Jing Xu, Xiaoyan Zhang, Yichuan Xiao, Xinfang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lei HanDepartment of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China.
Fengling HuangCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Qingchen ZhuCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Huan WangDepartment of Pharmacy, Hebei Medical University, Shijiazhuang 050011, China.
Tianlin LuDepartment of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China.
Chunyuan XiaoDepartment of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China.
Jing XuCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Xiaoyan ZhangDepartment of Renal and Rheumatology, Xin Hua Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Yichuan XiaoCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Xinfang HuangDepartment of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a complex pathogenesis that was previously thought to involve primarily adaptive immunity. Emerging evidence underscores the role of neutrophils in shaping immune dysregulation and inducing organ damage in lupus. This study aims to investigate the dynamics of neutrophil senescence and its relationship with lupus, an area that remains poorly understood. Here, we identify a significantly elevated proportion of CXCR4

Indexed as

Cellular SenescenceLupus Erythematosus, SystemicNeutrophilsAdultAutoantibodiesCD4-Positive T-LymphocytesFemaleHumansKiller Cells, NaturalMaleMiddle AgedReactive Oxygen SpeciesReceptors, CXCR4AutoantibodiesCXCR4 protein, humanReactive Oxygen SpeciesReceptors, CXCR4inhibitory capacityneutrophilsreactive oxygen speciessenescencesystemic lupus erythematosus

Identifiers

PMID40551712
PMCPMC12666659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.