Evidence map›Paper›PMID 40551711›Full record

ArticleActa biochimica et biophysica Sinica2025

Single-cell and bulk transcriptome analysis unveils a ligand-receptor-based signature for prognostication and reveals that TREM1 controls the malignant behaviors of hepatocellular carcinoma.

Jiemin Zhang, Qian Huang, Yingying Zheng, Jianqing Tang, Naling Kang, Yurui Liu, Dawu Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiemin ZhangDepartment of Pharmacy, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Qian HuangDepartment of Infectious Disease, Union Hospital, Fujian Medical University, Fuzhou 350000, China.
Yingying ZhengDepartment of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Clinical Research Center for Hepatopathy and Intestinal Diseases of Fujian Province, Fuzhou 350005, China; National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China.
Jianqing TangDepartment of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Naling KangDepartment of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Clinical Research Center for Hepatopathy and Intestinal Diseases of Fujian Province, Fuzhou 350005, China; National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China.
Yurui LiuDepartment of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Clinical Research Center for Hepatopathy and Intestinal Diseases of Fujian Province, Fuzhou 350005, China; National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China.
Dawu ZengDepartment of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Clinical Research Center for Hepatopathy and Intestinal Diseases of Fujian Province, Fuzhou 350005, China; National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional heterogeneity and cellular ecosystem diversity of HCC await further exploration. Single-cell and bulk RNA sequencing data from HCC cells are analyzed to generate a LASSO model for HCC prognostication. CCK-8, scratch assay, flow cytometry, and ROS assays are used to validate how TREM1 may affect HCC cell biological behaviors

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsTranscriptomeTriggering Receptor Expressed on Myeloid Cells-1AnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLigandsMaleMiceLigandsTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1ecosystemhepatocellular carcinomaimmune microenvironmentligand-receptor interactionTREM1

Identifiers

PMID40551711
PMCPMC12666666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.