ArticleJournal of genetic counseling2025
Preimplantation genetic testing for polygenic disorders: Viewpoints of reproductive genetic counselors and reproductive endocrinology and infertility specialists in the United States.
Article in Journal of genetic counseling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Public perceptions of polygenic testing and embryo selection for non-medical traits.Nature human behaviour · 2026Article
- Decision-making criteria in polygenic embryo screening: A survey of reproductive medicine physicians.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Survey of U.S. reproductive medicine clinicians' attitudes on polygenic embryo screening.NPJ genomic medicine · 2025Article
- Preimplantation genetic testing for polygenic disorders: Viewpoints of reproductive genetic counselors and reproductive endocrinology and infertility specialists in the United States.Journal of genetic counseling · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to assess awareness of preimplantation genetic testing (PGT) for polygenic disorders (PGT-P) and viewpoints surrounding PGT among reproductive genetic counselors (GCs) and reproductive endocrinology infertility physicians (REIs) in the United States. GCs and REIs were recruited via professional groups to complete an anonymous online survey that assessed awareness of PGT-P, motivating factors that are considered in recommending PGT-P and views on clinical use of PGT. In our sample of 82 GCs and 54 REIs, 80% reported having heard of PGT-P, 52% answered yes or maybe to whether patients should have the option of PGT-P for polygenic conditions, and only 18% answered yes or maybe to whether they would recommend it to their patients. REI participants (28%) were more likely to endorse recommending PGT-P in the context of in vitro fertilization + PGT for other indications compared to GC participants (12%) (p = 0.02). Advanced egg age and prior pregnancy history were the motivating factors that significantly differed between REI and GC participants in recommending PGT-P. In contrast to PGT-P, most participants (>96%) support patients having the option of PGT for aneuploidy, monogenic disorders of childhood and adult-onset conditions, and structural rearrangements. These findings warrant further research to better understand if GCs and REIs would recommend PGT-P in the future when more refined genetic risk estimates are developed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.