ArticleClinical and molecular hepatology2025
Factors associated with hepatitis B mother-to-child transmission in a national prevention program.
Article in Clinical and molecular hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Redefining MTCT prevention strategies toward HBV elimination: Editorial on "Factors associated with hepatitis B mother-to-child transmission in a national prevention program".Clinical and molecular hepatology · 2026Article
- Redefining MTCT prevention strategies toward HBV elimination: Correspondence to editorial on "Factors associated with hepatitis B mother-to-child transmission in a national prevention program".Clinical and molecular hepatology · 2026Article
- Reply to correspondence on "Factors associated with hepatitis B mother-to-child transmission in a national prevention program".Clinical and molecular hepatology · 2026Article
- Breaking the chain of perinatal hepatitis B transmission: Editorial on "Factors associated with hepatitis B mother-to-child transmission in a national prevention program".Clinical and molecular hepatology · 2026Article
- Factors influencing breastfeeding failure in mothers with hepatitis B infection: a qualitative study.Frontiers in nutrition · 2026Article
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4 authors.
Funding
Abstract
BACKGROUND/
aimsHepatitis B virus (HBV) mother-to-child transmission (MTCT) remains a global health concern, with over 90% of perinatal infections leading to chronic HBV. To evaluate long-term trends in MTCT rates and associated factors within Korea's national program.
methodsPopulation-based cohort study using linked data from the Perinatal Hepatitis B Prevention Program (PHBPP) and National Health Insurance Service in Korea. The study included HBsAg-positive mother-infant pairs with post-vaccination serologic results from 2002 to 2021.
resultsAmong the 154,478 mother-infant pairs, the overall MTCT rate after prophylaxis was 2.3%. Antiviral use lowered MTCT rates (0.9% vs. 2.4%) particularly in HBeAg-positivity (1.0% vs. 5.9%; adjusted odds ratio [aOR] 0.21; 95% confidence interval [CI] 0.14-0.32). Lower MTCT rates were observed for cesarean section vs. vaginal delivery (1.9% vs. 2.6%; aOR 0.78; 95% CI 0.73-0.84) and breastfeeding vs. formula feeding (1.8% vs. 2.8%; aOR 0.65; 95% CI 0.56-0.76). Annual MTCT rates decreased from 3.6% (2002-2005) to 1.3% (2018-2021). Antivirals reduced MTCT rates; initiation at 14-27 weeks (0.39%), or 28-32 weeks (0.44%) vs. ≥33 weeks (1.47%); postpartum continuation (0.55%) vs. antepartum discontinuation (1.44%); use ≥61 days (0.51%) vs. 1-60 days (1.67%). Lower MTCT risk was associated with maternal (old age, high income) and infant (female sex, preterm birth) factors.
conclusionThis comprehensive analysis of the PHBPP in Korea demonstrates that the use of antivirals, breastfeeding, and cesarean section, combined with conventional immunoprophylaxis, has significantly reduced MTCT rates. These results are crucial for global HBV elimination and can help to guide HBV MTCT prevention strategies.
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